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Abstract：
Breast cancer is the type of cancer with the highest prevalence in women worldwide. Skeletal muscle atrophy is an important prognostic factor in women diagnosed with breast cancer. This atrophy stems from disrupted skeletal muscle homeostasis, triggered by diminished anabolic signalling and heightened inflammatory conditions, culminating in an upregulation of skeletal muscle proteolysis gene expression. The importance of delving into research on modulators of skeletal muscle atrophy, such as microRNAs (miRNAs), which play a crucial role in regulating cellular signalling pathways involved in skeletal muscle protein synthesis and degradation, has been recognised. This holds true for conditions of homeostasis as well as pathologies like cancer. However, the determination of specific miRNAs that modulate skeletal muscle atrophy in breast cancer conditions has not yet been explored. In this narrative review, we aim to identify miRNAs that could directly or indirectly influence skeletal muscle atrophy in breast cancer models to gain an updated perspective on potential therapeutic targets that could be modulated through resistance exercise training, aiming to mitigate the loss of skeletal muscle mass in breast cancer patients.
摘要：
乳腺癌是全球女性患病率最高的癌症类型。骨骼肌萎缩是诊断为乳腺癌的女性的重要预后因素。这种萎缩源于骨骼肌稳态的破坏，由合成代谢信号减弱和炎症加剧引发，最终导致骨骼肌蛋白水解基因表达上调。深入研究骨骼肌萎缩调节剂研究的重要性，如microRNAs（miRNAs），在调节参与骨骼肌蛋白合成和降解的细胞信号通路中起着至关重要的作用，已被认可。这适用于稳态条件以及癌症等病理。然而,在乳腺癌疾病中调节骨骼肌萎缩的特定miRNA的确定尚未被探索。在这篇叙述性评论中，我们的目标是在乳腺癌模型中鉴定可能直接或间接影响骨骼肌萎缩的miRNA，以获得对可能通过抗阻运动训练调节的潜在治疗靶点的最新观点。旨在减轻乳腺癌患者骨骼肌质量的损失。
