PDF(Pubmed)
Abstract：
Microbes constitute the most prevalent life form on Earth, yet their remarkable diversity remains mostly unrecognized. Microbial diversity in vertebrate models presents a significant challenge for investigating host-microbiome interactions. The model organism Caenorhabditis elegans has many advantages for delineating the effects of host genetics on microbial composition. In the wild, the C. elegans gut contains various microbial species, while in the laboratory it is usually a host for a single bacterial species. There is a potential host-microbe interaction between microbial metabolites, drugs, and C. elegans phenotypes. This mini-review aims to summarize the current understanding regarding the microbiome in C. elegans. Examples using C. elegans to study host-microbe-metabolite interactions are discussed.
摘要：
微生物构成了地球上最普遍的生命形式，然而，他们非凡的多样性仍然大多没有得到承认。脊椎动物模型中的微生物多样性对研究宿主-微生物组相互作用提出了重大挑战。模型生物秀丽隐杆线虫在描述宿主遗传学对微生物组成的影响方面具有许多优势。在野外,秀丽隐杆线虫的肠道含有各种微生物，而在实验室中，它通常是单个细菌物种的宿主。微生物代谢物之间存在潜在的宿主-微生物相互作用，毒品,和秀丽隐杆线虫表型。这篇小型综述旨在总结目前对秀丽隐杆线虫微生物组的理解。讨论了使用秀丽隐杆线虫研究宿主-微生物-代谢物相互作用的示例。
