PDF(Pubmed)
Abstract：
The peripheral nervous system can encounter alterations due to exposure to some of the most commonly used anticancer drugs (platinum drugs, taxanes, vinca alkaloids, proteasome inhibitors, thalidomide), the so-called chemotherapy-induced peripheral neurotoxicity (CIPN). CIPN can be long-lasting or even permanent, and it is detrimental for the quality of life of cancer survivors, being associated with persistent disturbances such as sensory loss and neuropathic pain at limb extremities due to a mostly sensory axonal polyneuropathy/neuronopathy. In the state of the art, there is no efficacious preventive/curative treatment for this condition. Among the reasons for this unmet clinical and scientific need, there is an uncomplete knowledge of the pathogenetic mechanisms. Ion channels and transporters are pivotal elements in both the central and peripheral nervous system, and there is a growing body of literature suggesting that they might play a role in CIPN development. In this review, we first describe the biophysical properties of these targets and then report existing data for the involvement of ion channels and transporters in CIPN, thus paving the way for new approaches/druggable targets to cure and/or prevent CIPN.
摘要：
由于暴露于一些最常用的抗癌药物（铂类药物，紫杉烷,长春花生物碱，蛋白酶体抑制剂，沙利度胺)，所谓的化疗诱导的周围神经毒性（CIPN）。CIPN可以是持久的，甚至是永久的，这对癌症幸存者的生活质量有害，与由于主要是感觉轴索性多发性神经病/神经病引起的肢体四肢感觉丧失和神经性疼痛等持续性障碍有关。在最先进的技术中，这种情况没有有效的预防/治疗方法。在这种未满足的临床和科学需求的原因中，对致病机制有不完全的了解。离子通道和转运蛋白是中枢和周围神经系统的关键元件，越来越多的文献表明它们可能在CIPN的发展中发挥作用。在这次审查中,我们首先描述这些靶标的生物物理特性，然后报告有关CIPN中离子通道和转运蛋白参与的现有数据，从而为治愈和/或预防CIPN的新方法/可药物靶标铺平道路。
