PDF(Pubmed)
Abstract：
Staphylococcus aureus bacteremia continues to be associated with significant morbidity and mortality, despite improvements in diagnostics and management. Persistent infections pose a major challenge to clinicians and have been consistently shown to increase the risk of mortality and other infectious complications. S. aureus, while typically not considered an intracellular pathogen, has been proven to utilize an intracellular niche, through several phenotypes including small colony variants, as a means for survival that has been linked to chronic, persistent, and recurrent infections. This intracellular persistence allows for protection from the host immune system and leads to reduced antibiotic efficacy through a variety of mechanisms. These include antimicrobial resistance, tolerance, and/or persistence in S. aureus that contribute to persistent bacteremia. This review will discuss the challenges associated with treating these complicated infections and the various methods that S. aureus uses to persist within the intracellular space.
摘要：
金黄色葡萄球菌菌血症继续与显著的发病率和死亡率相关，尽管在诊断和管理方面有所改善。持续感染对临床医生构成重大挑战，并且一直被证明会增加死亡和其他感染并发症的风险。金黄色葡萄球菌，虽然通常不被认为是细胞内病原体，已经被证明可以利用细胞内的生态位，通过几种表型，包括小菌落变异，作为一种与慢性疾病有关的生存手段，持久性,和反复感染。这种细胞内持久性允许保护免受宿主免疫系统的影响，并通过多种机制导致抗生素功效降低。这些包括抗菌素耐药性，容忍度,和/或金黄色葡萄球菌的持久性，这有助于持续菌血症。这篇综述将讨论与治疗这些复杂感染相关的挑战以及金黄色葡萄球菌在细胞内空间内持续存在的各种方法。
