PDF(Pubmed)
Abstract：
The exact mechanism by which diabetic neuropathy develops is still not fully known, despite our advances in medical knowledge. Progressing neuropathy may occur with a persistently favorable metabolic status in some patients with diabetes mellitus, while, in others, though seldom, a persistently unfavorable metabolic status is not associated with significant neuropathy. This might be significantly due to genetic differences. While recent years have brought compelling progress in the understanding of the pathogenetic background-in particular, accelerated progress is being made in understanding molecular biological mechanisms-some aspects are still not fully understood. A comparatively small amount of information is accessible on this matter; therefore, by summarizing the available data, in this review, we aim to provide a clearer picture of the current state of knowledge, identify gaps in the previous studies, and possibly suggest directions for future studies. This could help in developing more personalized approaches to the prevention and treatment of diabetic neuropathy, while also taking into account individual genetic profiles.
摘要：
糖尿病性神经病的确切机制尚不完全清楚，尽管我们在医学知识上取得了进步。在一些糖尿病患者中，进展性神经病可能伴随着持续良好的代谢状态而发生。while,在其他方面,虽然很少，持续不利的代谢状态与显著的神经病变无关.这可能是由于遗传差异造成的。虽然近年来在理解致病背景方面取得了令人信服的进展，特别是，在理解分子生物学机制方面正在取得加速进展-某些方面仍未完全理解。关于这一问题的信息相对较少；因此，通过总结现有数据，在这次审查中,我们的目标是提供更清晰的知识现状，找出以前研究中的差距，并可能为未来的研究提供方向。这可能有助于开发更个性化的方法来预防和治疗糖尿病神经病变，同时还考虑到个人的遗传特征。
