PDF(Pubmed)
Abstract：
Histone chaperones are integral to chromatin dynamics, facilitating the assembly and disassembly of nucleosomes, thereby playing a crucial role in regulating gene expression and maintaining genomic stability. Moreover, they prevent aberrant histone interactions prior to chromatin assembly. Disruption in histone chaperone function may result in genomic instability, which is implicated in pathogenesis. This review aims to elucidate the role of histone chaperones in cancer pathologies and explore their potential as therapeutic targets. Histone chaperones have been found to be dysregulated in various cancers, with alterations in expression levels, mutations, or aberrant interactions leading to tumorigenesis and cancer progression. In addition, this review intends to highlight the molecular mechanisms of interactions between histone chaperones and oncogenic factors, underscoring their roles in cancer cell survival and proliferation. The dysregulation of histone chaperones is significantly correlated with cancer development, establishing them as active contributors to cancer pathology and viable targets for therapeutic intervention. This review advocates for continued research into histone chaperone-targeted therapies, which hold potential for precision medicine in oncology. Future advancements in understanding chaperone functions and interactions are anticipated to lead to novel cancer treatments, enhancing patient care and outcomes.
摘要：
组蛋白伴侣是染色质动力学不可或缺的部分，促进核小体的组装和拆卸，从而在调节基因表达和维持基因组稳定性中起着至关重要的作用。此外，它们在染色质组装之前防止异常的组蛋白相互作用。组蛋白伴侣功能的破坏可能导致基因组不稳定，这与发病机理有关。这篇综述旨在阐明组蛋白伴侣在癌症病理中的作用，并探讨其作为治疗靶点的潜力。已经发现组蛋白伴侣在各种癌症中失调，随着表达水平的改变，突变,或导致肿瘤发生和癌症进展的异常相互作用。此外,这篇综述旨在强调组蛋白伴侣与致癌因子相互作用的分子机制，强调它们在癌细胞存活和增殖中的作用。组蛋白伴侣的失调与癌症发展显着相关，将它们确立为癌症病理的积极贡献者和治疗干预的可行靶标。这篇综述主张继续研究组蛋白伴侣靶向疗法，这在肿瘤学中具有精准医学的潜力。在理解伴侣功能和相互作用方面的未来进步预计将导致新的癌症治疗。加强患者护理和结果。
