PDF(Pubmed)
Abstract：
Cannabinoids (the endocannabinoids, the synthetic cannabinoids, and the phytocannabinoids) are well known for their various pharmacological properties, including neuroprotective and anti-inflammatory features, which are fundamentally important for the treatment of neurodegenerative diseases. The aging of the global population is causing an increase in these diseases that require the development of effective drugs to be even more urgent. Taking into account the unavailability of effective drugs for neurodegenerative diseases, it seems appropriate to consider the role of cannabinoids in the treatment of these diseases. To our knowledge, few reviews are devoted to cannabinoids\' impact on modulating central and peripheral immunity in neurodegenerative diseases. The objective of this review is to provide the best possible information about the cannabinoid receptors and immuno-modulation features, peripheral immune modulation by cannabinoids, cannabinoid-based therapies for the treatment of neurological disorders, and the future development prospects of making cannabinoids versatile tools in the pursuit of effective drugs.
摘要：
大麻素（内源性大麻素，合成大麻素，和植物大麻素）以其各种药理特性而闻名，包括神经保护和抗炎功能，这对于治疗神经退行性疾病至关重要。全球人口的老龄化导致这些疾病的增加，需要开发有效的药物变得更加紧迫。考虑到缺乏治疗神经退行性疾病的有效药物，考虑大麻素在治疗这些疾病中的作用似乎是适当的。据我们所知,很少评论大麻素对调节神经退行性疾病中枢和外周免疫的影响。这篇综述的目的是提供关于大麻素受体和免疫调节特征的最佳信息，大麻素的外周免疫调节，基于大麻素的疗法，用于治疗神经系统疾病，以及在追求有效药物中制造大麻素多功能工具的未来发展前景。
