PDF(Pubmed)
Abstract：
Human papillomavirus (HPV) has been implicated in various cancers, including those affecting the skin. The study assessed the long-term risk of skin cancer associated with HPV infection in Taiwan region, using data from the National Health Insurance Research Database between 2007 and 2015. Our analysis revealed a significant increase in skin cancer risk among those with HPV, particularly for squamous cell carcinoma (SCC), the subtype with the highest observed adjusted hazard ratio (aHR) = 5.97, 95% CI: 4.96-7.19). The overall aHR for HPV-related skin cancer was 5.22 (95% CI: 4.70-5.80), indicating a notably higher risk in the HPV-positive group. The risk of skin cancer was further stratified by type, with basal cell carcinoma (aHR = 4.88, 95% CI: 4.14-5.74), and melanoma (aHR = 4.36, 95% CI: 2.76-6.89) also showing significant associations with HPV. The study also highlighted regional variations, with increased risks in southern Taiwan and the Kaohsiung-Pingtung area. Key findings emphasize the importance of sun protection, particularly in regions of high UV exposure and among individuals in high-risk occupations. This research contributes to a better understanding of the complex interactions between HPV and skin cancer risk, reinforcing the importance of preventive strategies in public health.
摘要：
人乳头瘤病毒（HPV）与各种癌症有关，包括那些影响皮肤的。这项研究评估了台湾地区与HPV感染相关的皮肤癌的长期风险，使用2007年至2015年国家健康保险研究数据库的数据。我们的分析显示，HPV患者患皮肤癌的风险显着增加，特别是对于鳞状细胞癌（SCC），观察到的校正风险比(aHR)最高的亚型=5.97,95%CI:4.96-7.19).HPV相关皮肤癌的总体aHR为5.22（95％CI：4.70-5.80），表明HPV阳性组的风险明显更高。皮肤癌的风险进一步按类型分层，基底细胞癌（aHR=4.88，95%CI：4.14-5.74），和黑色素瘤(aHR=4.36,95%CI:2.76-6.89)也显示与HPV显著相关。该研究还强调了区域差异，台湾南部和高雄-屏东地区的风险增加。主要发现强调了防晒的重要性，特别是在高紫外线暴露地区和高风险职业的个人中。这项研究有助于更好地理解HPV和皮肤癌风险之间的复杂相互作用。加强预防策略在公共卫生中的重要性。
