METHODS: This study enrolled 47 women with severe obesity (SO). The obtained anthropometric measurements included weight, height, neck (NC), waist (WC), and hip circumference (HC). Blood samples were collected to analyse glucose and lipid profiles, C-reactive protein, liver markers, adiponectin, and PAI-1 (determined by ELISA immunoassay). Homeostasis model assessment-adiponectin (HOMA-AD), homeostasis model assessment of insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), triglyceride-glucose index (TyG), and atherogenic index of plasma (AIP) were calculated. The women were grouped according to PAI-1 levels. The data were analysed using IBM SPSS Statistics, version 21. The significance level for the analysis was set at 5%.
RESULTS: Women with SO who have higher levels of PAI-1 have lower values of high-density lipoprotein cholesterol (HDL) (p = 0.037) and QUICKI (0.020) and higher values of HOMA-AD (0.046) and HOMA-IR (0.037). HOMA-IR was demonstrated to be a good predictor of PAI-1 in this sample (B = 0.2791; p = 0.017).
CONCLUSIONS: HOMA-IR could be used as a predictor of PAI-1 levels, pointing out the relevance of assessing glycaemic parameters for the prevention of CVDs in women with SO.
方法:本研究纳入了47名重度肥胖(SO)女性。获得的人体测量包括体重,高度,颈部(NC),腰部(WC),和臀围(HC)。收集血液样本以分析葡萄糖和脂质分布,C反应蛋白,肝脏标志物,脂联素,和PAI-1(通过ELISA免疫测定测定)。稳态模型评估-脂联素(HOMA-AD),胰岛素抵抗的稳态模型评估(HOMA-IR),定量胰岛素敏感性检查指数(QUICKI),甘油三酯-葡萄糖指数(TyG),计算血浆致动脉粥样硬化指数(AIP)。根据PAI-1水平对妇女进行分组。使用IBMSPSSStatistics分析数据,版本21.分析的显著性水平设定为5%。
结果:具有较高水平PAI-1的SO女性的高密度脂蛋白胆固醇(HDL)(p=0.037)和QUICKI(0.020)的值较低,而HOMA-AD(0.046)和HOMA-IR(0.037)的值较高。HOMA-IR被证明是该样品中PAI-1的良好预测因子(B=0.2791;p=0.017)。
结论:HOMA-IR可作为PAI-1水平的预测因子,指出评估血糖参数与预防女性SO患者心血管疾病的相关性。