关键词: acute myeloid leukemia; long non-coding RNA; tumor promoter; tumor suppressor; drug resistance; prognosis

Mesh : RNA, Long Noncoding / genetics Humans Leukemia, Myeloid, Acute / genetics Prognosis

来  源:   DOI:10.19746/j.cnki.issn.1009-2137.2024.03.051

Abstract:
In recent years, the importance of long non-coding RNA (lncRNA) in acute myeloid leukemia (AML) has attracted wide attention. Among them, lncRNAs that play a role in promoting cancer mainly include HOTAIR, UCA1, H19, ITGB2-AS1 and some genes of SNHG family, while in tumor suppression mainly include H22954, NEAT1, SNHG4, LINC01128 , etc. This article reviews the role of lncRNAs in the occurrence and development of AML, as well as those related to AML resistance and prognosis assessment, so as to provide a theoretical basis for the diagnosis and prognosis analysis of AML.
UNASSIGNED: 长链非编码RNA在急性髓细胞白血病发生发展中作用的研究进展.
UNASSIGNED: 近年来,长链非编码RNA(lncRNA)在急性髓细胞白血病(AML)中的重要性引起人们的广泛关注,其中发挥促癌作用的lncRNA主要有HOTAIR、UCA1、H19、ITGB2-AS1 和SNHG 家族的部分基因,而起抑癌作用的lncRNA主要有H22954、NEAT1、SNHG4、LINC01128等。本文就lncRNA在AML发生发展中的作用以及与AML耐药和预后判断相关的lncRNA进行综述,以期为AML的诊断和预后分析提供理论依据。 .
摘要:
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