%0 Journal Article
%T [Research Progress on Role of Long Non-Coding RNA in Occurrence and Development of Acute Myeloid Leukemia--Review].
%A Lu XS
%A Wang XQ
%A DU YN
%A Zhang JH
%J Zhongguo Shi Yan Xue Ye Xue Za Zhi
%V 32
%N 3
%D 2024 Jun
%M 38926999
暂无%R 10.19746/j.cnki.issn.1009-2137.2024.03.051
%X In recent years, the importance of long non-coding RNA (lncRNA) in acute myeloid leukemia (AML) has attracted wide attention. Among them, lncRNAs that play a role in promoting cancer mainly include HOTAIR, UCA1, H19, ITGB2-AS1 and some genes of SNHG family, while in tumor suppression mainly include H22954, NEAT1, SNHG4, LINC01128 , etc. This article reviews the role of lncRNAs in the occurrence and development of AML, as well as those related to AML resistance and prognosis assessment, so as to provide a theoretical basis for the diagnosis and prognosis analysis of AML.<BR><B>UNASSIGNED: </B>长链非编码RNA在急性髓细胞白血病发生发展中作用的研究进展.<BR><B>UNASSIGNED: </B>近年来，长链非编码RNA（lncRNA）在急性髓细胞白血病（AML）中的重要性引起人们的广泛关注，其中发挥促癌作用的lncRNA主要有HOTAIR、UCA1、H19、ITGB2-AS1 和SNHG 家族的部分基因，而起抑癌作用的lncRNA主要有H22954、NEAT1、SNHG4、LINC01128等。本文就lncRNA在AML发生发展中的作用以及与AML耐药和预后判断相关的lncRNA进行综述，以期为AML的诊断和预后分析提供理论依据。 .