PDF(Pubmed)
Abstract：
BACKGROUND: An increasing body of evidence suggests that home-based exercise (HBE) therapy has significant therapeutic effects on knee osteoarthritis (KOA) and hip osteoarthritis (HipOA), and it has advantages such as cost savings, strong operability, and good compliance compared with hospitalization and exercise courses.
OBJECTIVE: To evaluate the efficacy of HBE in the treatment of KOA and HipOA.
METHODS: A systematic search was conducted in PubMed, Cochrane, Web of Science, and Embase to collect randomized controlled trials. The retrieval time was from database establishment until March 6, 2024. Stata 15.1 software was used for data analysis.
RESULTS: A total of 16 randomized controlled trials involving 3,015participants were included, with 1,519 participants in the intervention group and 1,496 in the control group. The meta-analysis showed that, compared to the control group, HBE can significantly improve pain [SMD=-0.38, 95% CI (-0.58, -0.18); P = 0.001], joint function [SMD=-0.60, 95% CI (-1.01, -0.19); P = 0.004], balance ability [SMD=-0.67, 95% CI (-1.00, -0.34); P = 0.001], mobility (ADL) [SMD = 0.51, 95% CI (0.19, 0.82); P = 0.002] in patients with KOA and HipOA. There is no statistical difference in the improvement of joint stiffness [WMD = -0.80, 95% CI (-1.61, 0.01); P = 0.052]. In addition, subgroup analysis showed that HBE significantly improved pain, joint function, and balance ability in KOA patients compared with the control group. HipOA patients showed significant improvement in pain and joint function; However, HBE only improved activity ability in patients with comorbidities of KOA and HipOA.
CONCLUSIONS: HBE can effectively alleviate pain, improve joint function, and enhance physical function in patients with KOA and HipOA. However, more high-quality randomized controlled trials (RCTs) with large sample sizes and long-term interventions are needed to validate the efficacy of HBE due to limitations in the methodology and consistency of indicator outcomes in the included RCTs.
BACKGROUND: We\'ve registered with PROSPERO, and the number is CRD42023443085.
OBJECTIVE: To evaluate the efficacy of HBE in the treatment of KOA and HipOA.
METHODS: A systematic search was conducted in PubMed, Cochrane, Web of Science, and Embase to collect randomized controlled trials. The retrieval time was from database establishment until March 6, 2024. Stata 15.1 software was used for data analysis.
RESULTS: A total of 16 randomized controlled trials involving 3,015participants were included, with 1,519 participants in the intervention group and 1,496 in the control group. The meta-analysis showed that, compared to the control group, HBE can significantly improve pain [SMD=-0.38, 95% CI (-0.58, -0.18); P = 0.001], joint function [SMD=-0.60, 95% CI (-1.01, -0.19); P = 0.004], balance ability [SMD=-0.67, 95% CI (-1.00, -0.34); P = 0.001], mobility (ADL) [SMD = 0.51, 95% CI (0.19, 0.82); P = 0.002] in patients with KOA and HipOA. There is no statistical difference in the improvement of joint stiffness [WMD = -0.80, 95% CI (-1.61, 0.01); P = 0.052]. In addition, subgroup analysis showed that HBE significantly improved pain, joint function, and balance ability in KOA patients compared with the control group. HipOA patients showed significant improvement in pain and joint function; However, HBE only improved activity ability in patients with comorbidities of KOA and HipOA.
CONCLUSIONS: HBE can effectively alleviate pain, improve joint function, and enhance physical function in patients with KOA and HipOA. However, more high-quality randomized controlled trials (RCTs) with large sample sizes and long-term interventions are needed to validate the efficacy of HBE due to limitations in the methodology and consistency of indicator outcomes in the included RCTs.
BACKGROUND: We\'ve registered with PROSPERO, and the number is CRD42023443085.
摘要：
背景：越来越多的证据表明，以家庭为基础的运动（HBE）疗法对膝骨关节炎（KOA）和髋骨关节炎（HipOA）具有显着的治疗效果，它具有节约成本等优点，操作性强,与住院和运动课程相比，依从性良好。
目的：评价HBE治疗KOA和HipOA的疗效。
方法：在PubMed中进行了系统搜索，科克伦,WebofScience,和Embase收集随机对照试验。检索时间从数据库建立到2024年3月6日。采用Stata15.1软件进行数据分析。
结果：共纳入16项随机对照试验，涉及3,015名参与者，干预组1,519名参与者，对照组1,496名参与者。荟萃分析表明,与对照组相比，HBE能显著改善疼痛[SMD=-0.38,95%CI(-0.58,-0.18);P=0.001],关节功能[SMD=-0.60，95%CI(-1.01，-0.19)；P=0.004]，平衡能力[SMD=-0.67，95%CI(-1.00，-0.34)；P=0.001]，运动性(ADL)[SMD=0.51,95%CI(0.19,0.82);P=0.002]关节刚度的改善无统计学差异[WMD=-0.80,95%CI(-1.61,0.01);P=0.052]。此外,亚组分析显示，HBE显著改善疼痛，联合功能，KOA患者平衡能力与对照组比较。HipOA患者的疼痛和关节功能均有显著改善;然而,HBE仅改善KOA和HipOA合并症患者的活动能力。
结论：HBE能有效缓解疼痛，改善关节功能，并增强KOA和HipOA患者的身体功能。然而,由于纳入的随机对照试验的方法学局限性和指标结局的一致性,需要更多具有大样本量和长期干预的高质量随机对照试验(RCT)来验证HBE的疗效.
背景：我们已在PROSPERO注册，号码是CRD42023443085。
目的：评价HBE治疗KOA和HipOA的疗效。
方法：在PubMed中进行了系统搜索，科克伦,WebofScience,和Embase收集随机对照试验。检索时间从数据库建立到2024年3月6日。采用Stata15.1软件进行数据分析。
结果：共纳入16项随机对照试验，涉及3,015名参与者，干预组1,519名参与者，对照组1,496名参与者。荟萃分析表明,与对照组相比，HBE能显著改善疼痛[SMD=-0.38,95%CI(-0.58,-0.18);P=0.001],关节功能[SMD=-0.60，95%CI(-1.01，-0.19)；P=0.004]，平衡能力[SMD=-0.67，95%CI(-1.00，-0.34)；P=0.001]，运动性(ADL)[SMD=0.51,95%CI(0.19,0.82);P=0.002]关节刚度的改善无统计学差异[WMD=-0.80,95%CI(-1.61,0.01);P=0.052]。此外,亚组分析显示，HBE显著改善疼痛，联合功能，KOA患者平衡能力与对照组比较。HipOA患者的疼痛和关节功能均有显著改善;然而,HBE仅改善KOA和HipOA合并症患者的活动能力。
结论：HBE能有效缓解疼痛，改善关节功能，并增强KOA和HipOA患者的身体功能。然而,由于纳入的随机对照试验的方法学局限性和指标结局的一致性,需要更多具有大样本量和长期干预的高质量随机对照试验(RCT)来验证HBE的疗效.
背景：我们已在PROSPERO注册，号码是CRD42023443085。
