关键词: Clinical trials Customized fluid Fluid therapy Hartmann’s solution Ionic concentration Pig physiology

Mesh : Animals Fluid Therapy / veterinary methods Swine Dehydration / veterinary therapy Female Swine Diseases / therapy Male Hematocrit / veterinary

来  源:   DOI:10.1186/s12917-024-04145-1   PDF(Pubmed)

Abstract:
BACKGROUND: Fluid therapy in veterinary medicine is pivotal for treating various conditions in pigs; however, standard solutions, such as Hartmann\'s solution, may not optimally align with pig physiology. This study explored the development and efficacy of a customized fluid therapy tailored to the ionic concentrations of pig blood, aiming to enhance treatment outcomes and safety in both healthy and diseased pigs.
RESULTS: The study involved two experiments: the first to assess the safety and stability of customized fluids in healthy pigs, and the second to evaluate the efficacy in pigs with clinical symptoms of dehydration. In healthy pigs, the administration of customized fluids showed no adverse effects, with slight alterations observed in pO2, hematocrit, and glucose levels in some groups. In symptomatic pigs, the customized fluid group did not show any improvement in clinical symptoms, with no significant changes in blood chemistry or metabolite levels compared to controls. The customized fluid group showed a mild increase in some values after administration, yet within normal physiological ranges. The study reported no significant improvements in clinical or dehydration status, attributing the observed variations in blood test results to the limited sample size and anaesthesia effects rather than fluid characteristics.
CONCLUSIONS: Customized fluid therapy, tailored to mimic the ionic concentrations of pig blood, appears to be a safe and potentially more effective alternative to conventional solutions such as Hartmann\'s solution for treating pigs under various health conditions. Further research with larger sample sizes and controlled conditions is recommended to validate these findings and to explore the full potential of customized fluid therapy in veterinary practice.
摘要:
背景:兽医学中的液体疗法对于治疗猪的各种疾病至关重要;然而,标准溶液,比如哈特曼的解决方案,可能无法最佳地与猪的生理学保持一致。这项研究探索了针对猪血离子浓度定制的液体疗法的开发和功效,旨在提高健康和患病猪的治疗效果和安全性。
结果:该研究涉及两个实验:第一个评估健康猪定制液体的安全性和稳定性,其次是对有临床症状的脱水猪的疗效评价。在健康的猪中,定制液体的给药没有不良反应,在PO2,血细胞比容中观察到轻微的变化,和某些组的葡萄糖水平。在有症状的猪中,定制液体组未显示任何临床症状改善,与对照组相比,血液化学或代谢物水平没有显着变化。定制流体组在给药后显示一些值的轻度增加,但在正常生理范围内。该研究报告临床或脱水状态没有显着改善,将观察到的血液测试结果的变化归因于有限的样本量和麻醉效果,而不是液体特征。
结论:定制液体疗法,专门模拟猪血的离子浓度,似乎是一种安全和可能更有效的替代传统的解决方案,如哈特曼的解决方案,用于治疗猪在各种健康条件下。建议使用更大的样本量和受控条件进行进一步研究,以验证这些发现并探索兽医实践中定制液体治疗的全部潜力。
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