PDF(Pubmed)
Abstract：
Zoonotic yeast species have been implicated in disease development in both humans and cats. This study analyzed the yeast mycobiota present in feline facial hair and human nails and explored potential interspecies associations. A total of 118 biological specimens were examined, including 59 feline facial hair and 59 human nail samples. DNA extraction and DNA sequencing were performed to identify the specific yeast species. The most predominant yeast species in humans and cats were selected for antifungal susceptibility testing (itraconazole, ketoconazole, miconazole, and terbinafine). The findings unveiled diverse yeast species in cats and humans. Malassezia pachydermatis (45.8%) and Malassezia furfur (30.5%) were the most common yeast species in cats and humans, respectively. However, no significant correlation was detected between the yeast species identified in cats and their owners residing in the same household (p > 0.05). Miconazole exhibited the highest minimum inhibitory concentrations (MICs) against Malassezia pachydermatis and Malassezia furfur in both cat and human isolates, whereas terbinafine showed the lowest MICs against most Malassezia pachydermatis and Malassezia furfur in both cat and human isolates. Diverse yeast species in cat facial hair and human nails suggest possible cross-contamination among humans, pets, and environments.
摘要：
人畜共患酵母菌种与人和猫的疾病发展有关。这项研究分析了猫科动物面部毛发和人类指甲中存在的酵母分枝杆菌群，并探索了潜在的种间关联。共检查了118份生物标本,包括59个猫科动物面部毛发和59个人类指甲样本。进行DNA提取和DNA测序以鉴定特定的酵母种类。选择人和猫中最主要的酵母菌种进行抗真菌药敏试验（伊曲康唑，酮康唑,咪康唑,和特比萘芬）。研究结果揭示了猫和人类中的多种酵母种类。在猫和人类中最常见的酵母菌是马拉色菌（45.8％）和糠马拉色菌（30.5％），分别。然而,在猫中鉴定的酵母菌种与其居住在同一家庭的主人之间没有检测到显著的相关性(p>0.05)。咪康唑在猫和人类分离物中对厚皮马拉色菌和糠马拉色菌均表现出最高的最低抑制浓度（MIC）。而特比萘芬在猫和人类分离物中对大多数厚皮马拉色菌和糠马拉色菌的MIC最低。猫面部毛发和人指甲中的多种酵母种类表明人类之间可能存在交叉污染，宠物,和环境。
