Abstract：
OBJECTIVE: The aim of this study was to evaluate the lamina cribrosa curvature index in different types of glaucoma in comparison with clinical findings and conventional measurement methods.
METHODS: Patients older than 18 years who were followed up in Glaucoma Unit of Department of Ophthalmology at Fırat University Faculty of Medicine, whose disease had been under control at least for 1 year, who had at least three reliable visual fields, whose refractive error was between - 6 and + 5 diopter and who did not have any disease other than glaucoma that would affect the visual field, were included in the study. Clinical and demographic characteristics, visual field, optical coherence tomography and lamina cribrosa curvature index (LCCI) results were evaluated. The study patients were divided into six groups: early-stage primary open-angle glaucoma (POAG) as group 1 and intermediate-advanced stage POAG as group 2, pseudo-exfoliation glaucoma (PEXG) as group 3, normal tension glaucoma (NTG) as group 4, ocular hypertension patients whom subsequently developed POAG as group 5 and healthy control as group 6.
RESULTS: A total of 189 eyes of 101 patients were included in our study. Forty-seven patients were male (46.5%) and 54 were female (53.5%). The mean age was 62.43 ± 1.49 years. LCCI, mean deviation (MD), visual field index (VFI), pattern standard deviation (PSD) and retinal nerve fiber layer thickness (RNFL) values were analyzed in all groups and Pearson correlation analysis showed statistically significant correlation between PSD and RNFL measurements with LCCI values in all groups. MD value was correlated with LCCI in groups 2, 3 and 4, while VFI value was correlated with LCCI in all groups except group 5. When the groups were compared with each other according to the Post-Hoc Tamhane test, LCCI measurement showed statistically significant results in accordance with MD, VFI, PSD and RNFL values.
CONCLUSIONS: The LCCI assessment is mostly consistent with conventional tests. In this study, in which different types of glaucoma and healthy subjects were examined simultaneously, LCCI shows promise as a detailed and reliable assessment method.
METHODS: Patients older than 18 years who were followed up in Glaucoma Unit of Department of Ophthalmology at Fırat University Faculty of Medicine, whose disease had been under control at least for 1 year, who had at least three reliable visual fields, whose refractive error was between - 6 and + 5 diopter and who did not have any disease other than glaucoma that would affect the visual field, were included in the study. Clinical and demographic characteristics, visual field, optical coherence tomography and lamina cribrosa curvature index (LCCI) results were evaluated. The study patients were divided into six groups: early-stage primary open-angle glaucoma (POAG) as group 1 and intermediate-advanced stage POAG as group 2, pseudo-exfoliation glaucoma (PEXG) as group 3, normal tension glaucoma (NTG) as group 4, ocular hypertension patients whom subsequently developed POAG as group 5 and healthy control as group 6.
RESULTS: A total of 189 eyes of 101 patients were included in our study. Forty-seven patients were male (46.5%) and 54 were female (53.5%). The mean age was 62.43 ± 1.49 years. LCCI, mean deviation (MD), visual field index (VFI), pattern standard deviation (PSD) and retinal nerve fiber layer thickness (RNFL) values were analyzed in all groups and Pearson correlation analysis showed statistically significant correlation between PSD and RNFL measurements with LCCI values in all groups. MD value was correlated with LCCI in groups 2, 3 and 4, while VFI value was correlated with LCCI in all groups except group 5. When the groups were compared with each other according to the Post-Hoc Tamhane test, LCCI measurement showed statistically significant results in accordance with MD, VFI, PSD and RNFL values.
CONCLUSIONS: The LCCI assessment is mostly consistent with conventional tests. In this study, in which different types of glaucoma and healthy subjects were examined simultaneously, LCCI shows promise as a detailed and reliable assessment method.
摘要：
目的：本研究的目的是评估不同类型青光眼的筛板曲率指数，并与临床发现和常规测量方法进行比较。
方法：在费拉特大学医学院眼科青光眼室随访的18岁以上患者，他们的疾病至少得到了1年的控制，至少有三个可靠的视野，他们的屈光度在-6到+5屈光度之间，除了青光眼之外没有任何会影响视野的疾病，包括在研究中。临床和人口统计学特征，视野,评估光学相干断层扫描和筛板曲率指数（LCCI）的结果。将研究患者分为6组：早期原发性开角型青光眼（POAG）为1组，中晚期POAG为2组，假性剥脱性青光眼（PEXG）为3组，正常眼压性青光眼（NTG）为4组，随后发展为POAG的高眼压患者为5组，健康对照组为6组。
结果：本研究共纳入101例患者的189只眼。47例患者为男性（46.5％），54例为女性（53.5％）。平均年龄为62.43±1.49岁。LCCI，平均偏差(MD)，视野指数（VFI），在所有组中分析了模式标准偏差（PSD）和视网膜神经纤维层厚度（RNFL）值，Pearson相关性分析显示，在所有组中，PSD和RNFL测量值与LCCI值之间具有统计学上的显着相关性。在第2、3和4组中，MD值与LCCI相关，而除第5组外，所有组的VFI值与LCCI相关。当根据事后Tamhane检验将各组进行比较时，LCCI测量显示具有统计学意义的结果与MD一致，VFI,PSD和RNFL值。
结论：LCCI评估与常规测试基本一致。在这项研究中,同时检查不同类型的青光眼和健康受试者，LCCI有望成为一种详细可靠的评估方法。
方法：在费拉特大学医学院眼科青光眼室随访的18岁以上患者，他们的疾病至少得到了1年的控制，至少有三个可靠的视野，他们的屈光度在-6到+5屈光度之间，除了青光眼之外没有任何会影响视野的疾病，包括在研究中。临床和人口统计学特征，视野,评估光学相干断层扫描和筛板曲率指数（LCCI）的结果。将研究患者分为6组：早期原发性开角型青光眼（POAG）为1组，中晚期POAG为2组，假性剥脱性青光眼（PEXG）为3组，正常眼压性青光眼（NTG）为4组，随后发展为POAG的高眼压患者为5组，健康对照组为6组。
结果：本研究共纳入101例患者的189只眼。47例患者为男性（46.5％），54例为女性（53.5％）。平均年龄为62.43±1.49岁。LCCI，平均偏差(MD)，视野指数（VFI），在所有组中分析了模式标准偏差（PSD）和视网膜神经纤维层厚度（RNFL）值，Pearson相关性分析显示，在所有组中，PSD和RNFL测量值与LCCI值之间具有统计学上的显着相关性。在第2、3和4组中，MD值与LCCI相关，而除第5组外，所有组的VFI值与LCCI相关。当根据事后Tamhane检验将各组进行比较时，LCCI测量显示具有统计学意义的结果与MD一致，VFI,PSD和RNFL值。
结论：LCCI评估与常规测试基本一致。在这项研究中,同时检查不同类型的青光眼和健康受试者，LCCI有望成为一种详细可靠的评估方法。
