Abstract：
OBJECTIVE: To evaluate and compare the effect of dexamethasone, ketoprofen and cold compress on the quality of life (QoL) following surgical removal of impacted lower third molars (ILTMs).
METHODS: Eligible patients requiring ILTM extraction with a modified Pederson difficulty index score of 5-6 were recruited. The patients were randomly allocated into Groups A, B and C. Groups A and C received 100 mg of ketoprofen and 8 mg of dexamethasone per-oral respectively, preoperatively. Subjects in group B applied a pre-standardized ice pack over the angle of the mandible for 6 h postoperatively. The QoL questionnaire was administered on postoperative days 1, 2 and 7.
RESULTS: In total, seventy-eight subjects completed the study: 46 (59%) were male and had a mean age of 27.8 ± 4.9 years. The groups were similar sociodemographically. The overall QoL and appearance domain score were significantly better in patients on oral dexamethasone on postoperative day 1 than in the other groups.
CONCLUSIONS: Oral dexamethasone demonstrates better improvement in postoperative QoL and appearance on day 1 following ILTM surgery compared to ice packs and ketoprofen. Although ice packs are readily available, can be used repeatedly and are a low-cost option, more research is necessary to determine their optimum therapeutic use in outpatient settings.
CONCLUSIONS: Oral dexamethasone is superior to ice pack compress and ketoprofen in improving the postoperative QoL in ILTM surgery.
UNASSIGNED: PACTR202005593102009 at Pan African Clinical Trial Registry.
METHODS: Eligible patients requiring ILTM extraction with a modified Pederson difficulty index score of 5-6 were recruited. The patients were randomly allocated into Groups A, B and C. Groups A and C received 100 mg of ketoprofen and 8 mg of dexamethasone per-oral respectively, preoperatively. Subjects in group B applied a pre-standardized ice pack over the angle of the mandible for 6 h postoperatively. The QoL questionnaire was administered on postoperative days 1, 2 and 7.
RESULTS: In total, seventy-eight subjects completed the study: 46 (59%) were male and had a mean age of 27.8 ± 4.9 years. The groups were similar sociodemographically. The overall QoL and appearance domain score were significantly better in patients on oral dexamethasone on postoperative day 1 than in the other groups.
CONCLUSIONS: Oral dexamethasone demonstrates better improvement in postoperative QoL and appearance on day 1 following ILTM surgery compared to ice packs and ketoprofen. Although ice packs are readily available, can be used repeatedly and are a low-cost option, more research is necessary to determine their optimum therapeutic use in outpatient settings.
CONCLUSIONS: Oral dexamethasone is superior to ice pack compress and ketoprofen in improving the postoperative QoL in ILTM surgery.
UNASSIGNED: PACTR202005593102009 at Pan African Clinical Trial Registry.
摘要：
目的：评估和比较地塞米松的效果，酮洛芬和冷敷对手术切除受影响的下第三磨牙（ILTMs）后的生活质量（QoL）。
方法：招募需要ILTM提取的合格患者，其改良的Pederson难度指数评分为5-6。将患者随机分为A组,B和C组分别口服100毫克酮洛芬和8毫克地塞米松，术前。B组的受试者在术后6小时内将预先标准化的冰袋应用于下颌骨的角度。QoL问卷在术后第1、2和7天进行。
结果：总计，78名受试者完成了研究:46名(59%)为男性,平均年龄为27.8±4.9岁。两组在社会人口统计学上相似。术后第1天口服地塞米松的患者的总体QoL和外观领域评分明显优于其他组。
结论：与冰袋和酮洛芬相比，口服地塞米松在ILTM手术后第1天的术后QoL和外观上显示出更好的改善。虽然冰袋很容易买到，可以重复使用，是一种低成本的选择，需要更多的研究来确定其在门诊环境中的最佳治疗用途.
结论：在改善ILTM手术的术后生活质量方面，口服地塞米松优于冰袋压缩和酮洛芬。
■PACTR202005593102009，泛非临床试验注册。
方法：招募需要ILTM提取的合格患者，其改良的Pederson难度指数评分为5-6。将患者随机分为A组,B和C组分别口服100毫克酮洛芬和8毫克地塞米松，术前。B组的受试者在术后6小时内将预先标准化的冰袋应用于下颌骨的角度。QoL问卷在术后第1、2和7天进行。
结果：总计，78名受试者完成了研究:46名(59%)为男性,平均年龄为27.8±4.9岁。两组在社会人口统计学上相似。术后第1天口服地塞米松的患者的总体QoL和外观领域评分明显优于其他组。
结论：与冰袋和酮洛芬相比，口服地塞米松在ILTM手术后第1天的术后QoL和外观上显示出更好的改善。虽然冰袋很容易买到，可以重复使用，是一种低成本的选择，需要更多的研究来确定其在门诊环境中的最佳治疗用途.
结论：在改善ILTM手术的术后生活质量方面，口服地塞米松优于冰袋压缩和酮洛芬。
■PACTR202005593102009，泛非临床试验注册。
