关键词: -node radiation therapy Dose de-escalation Involved Modified dog-leg Para-aortic strip Proton radiation Radiation therapy Testicular seminoma

Mesh : Humans Male Testicular Neoplasms / radiotherapy Seminoma / radiotherapy Radiotherapy, Adjuvant Orchiectomy Neoplasm Staging Neoplasms, Germ Cell and Embryonal / radiotherapy Radiotherapy Dosage Neoplasm Recurrence, Local / prevention & control

来  源:   DOI:10.1016/j.ucl.2024.03.008

Abstract:
Testicular cancer is a rare but curable male malignancy. Seminoma represents the majority of germ cell tumors and is considered radiation sensitive. Radiation treatment plays a role in adjuvant therapy after orchiectomy of stage I, IIA, and IIB seminomas. Radiation dose de-escalation has been effective in preventing tumor recurrences while also limiting acute and long-term toxicities. However, long-term risks, including the prevailing concern of secondary malignancy risk, between adjuvant radiation and chemotherapy play a role in recommendations. Ongoing work continues to be performed to reduce radiation field and dose in combination with chemotherapy while still maintaining excellent outcomes.
摘要:
睾丸癌是一种罕见但可治愈的男性恶性肿瘤。精原细胞瘤代表大多数生殖细胞肿瘤,被认为对辐射敏感。放射治疗在I期睾丸切除术后的辅助治疗中起作用,IIA,和IIB精原细胞瘤。辐射剂量递减在预防肿瘤复发同时也限制急性和长期毒性方面是有效的。然而,长期风险,包括普遍关注的继发性恶性肿瘤风险,在辅助放疗和化疗之间起作用的建议。正在进行的工作将继续进行,以减少与化疗结合的放射场和剂量,同时仍然保持良好的结果。
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