Abstract：
BACKGROUND: Recently, reports of endoscopic approaches for neuroblastoma, ganglioneuroblastoma, and ganglioneuroma (peripheral neuroblastic tumor; PNTs) have been increasing. This study aimed to clarify the indications for endoscopic surgery for PNTs.
METHODS: Pediatric patients who underwent endoscopic surgery for PNTs at our institution were included in this study. Image-defined risk factors (IDRFs) were analyzed using preoperative computed tomography (CT).
RESULTS: Twenty-four patients underwent endoscopic surgery for PNTs. The diagnoses included neuroblastoma (n = 11), ganglioneuroma (n = 10), and ganglioneuroblastoma (n = 3). Regarding the tumor site, there were 18 cases of adrenal tumors, five cases of mediastinal tumors, and one case of retroperitoneal tumors. Image-defined risk factors were positive in eight cases (contacted with a renal vessel, n = 6; compression of principal bronchi, n = 2). Complete resection was accomplished in 21 cases (14 of 16 IDRF-negative cases and seven of eight IDRF-positive cases). All patients survived without recurrence during the follow-up period.
CONCLUSIONS: The CT findings of contact with renal vessels and compression of principal bronchi do not seem to be indicators of incomplete resection. An endoscopic approach to PNTs in pediatric patients is feasible with a good prognosis if patients are selected strictly.
METHODS: Pediatric patients who underwent endoscopic surgery for PNTs at our institution were included in this study. Image-defined risk factors (IDRFs) were analyzed using preoperative computed tomography (CT).
RESULTS: Twenty-four patients underwent endoscopic surgery for PNTs. The diagnoses included neuroblastoma (n = 11), ganglioneuroma (n = 10), and ganglioneuroblastoma (n = 3). Regarding the tumor site, there were 18 cases of adrenal tumors, five cases of mediastinal tumors, and one case of retroperitoneal tumors. Image-defined risk factors were positive in eight cases (contacted with a renal vessel, n = 6; compression of principal bronchi, n = 2). Complete resection was accomplished in 21 cases (14 of 16 IDRF-negative cases and seven of eight IDRF-positive cases). All patients survived without recurrence during the follow-up period.
CONCLUSIONS: The CT findings of contact with renal vessels and compression of principal bronchi do not seem to be indicators of incomplete resection. An endoscopic approach to PNTs in pediatric patients is feasible with a good prognosis if patients are selected strictly.
摘要：
背景：最近，神经母细胞瘤内镜入路的报告，神经节神经母细胞瘤,和神经节神经瘤（周围神经母细胞瘤；PNTs）一直在增加。本研究旨在阐明内镜手术治疗PNTs的适应证。
方法：本研究包括在我们机构接受内镜下PNTs手术的儿科患者。使用术前计算机断层扫描（CT）分析图像定义的危险因素（IDRF）。
结果：24例患者接受内镜手术治疗。诊断包括神经母细胞瘤（n=11），神经节神经瘤（n=10），和神经节神经母细胞瘤（n=3）。关于肿瘤部位，肾上腺肿瘤18例,纵隔肿瘤5例,腹膜后肿瘤1例.图像定义的危险因素在8例中呈阳性（与肾血管接触，n=6；主支气管压缩，n=2)。21例完成了完全切除（16例IDRF阴性病例中的14例和8例IDRF阳性病例中的7例）。所有患者在随访期间均存活，无复发。
结论：与肾血管接触和主支气管受压的CT表现似乎不是不完全切除的指标。如果严格选择患者，则在儿科患者中对PNTs进行内镜检查是可行的，预后良好。
方法：本研究包括在我们机构接受内镜下PNTs手术的儿科患者。使用术前计算机断层扫描（CT）分析图像定义的危险因素（IDRF）。
结果：24例患者接受内镜手术治疗。诊断包括神经母细胞瘤（n=11），神经节神经瘤（n=10），和神经节神经母细胞瘤（n=3）。关于肿瘤部位，肾上腺肿瘤18例,纵隔肿瘤5例,腹膜后肿瘤1例.图像定义的危险因素在8例中呈阳性（与肾血管接触，n=6；主支气管压缩，n=2)。21例完成了完全切除（16例IDRF阴性病例中的14例和8例IDRF阳性病例中的7例）。所有患者在随访期间均存活，无复发。
结论：与肾血管接触和主支气管受压的CT表现似乎不是不完全切除的指标。如果严格选择患者，则在儿科患者中对PNTs进行内镜检查是可行的，预后良好。
