Abstract：
Bacterial therapy is recognized as a cost-effective treatment for several diseases. However, its development is hindered by limited functionality, weak inherent therapeutic effects, and vulnerability to harsh microenvironmental conditions, leading to suboptimal treatment activity. Enhancing bacterial activity and therapeutic outcomes emerges as a pivotal challenge. Nanozymes have garnered significant attention due to their enzyme-mimic activities and high stability. They enable bacteria to mimic the functions of gene-edited bacteria expressing the same functional enzymes, thereby improving bacterial activity and therapeutic efficacy. This review delineates the therapeutic mechanisms of bacteria and nanozymes, followed by a summary of strategies for preparing bacteria/nanozyme composites. Additionally, the synergistic effects of such composites in biomedical applications such as gastrointestinal diseases and tumors are highlighted. Finally, the challenges of bacteria/nanozyme composites are discussed and propose potential solutions. This study aims to provide valuable insights to offer theoretical guidance for the advancement of nanomaterial-assisted bacterial therapy.
摘要：
细菌疗法被认为是几种疾病的具有成本效益的治疗方法。然而,它的发展受到有限功能的阻碍，弱的固有治疗效果，以及对恶劣微环境条件的脆弱性，导致次优的治疗活动。增强细菌活性和治疗结果是一个关键的挑战。纳米酶由于其酶模拟活性和高稳定性而引起了极大的关注。它们使细菌能够模拟表达相同功能酶的基因编辑细菌的功能，从而提高细菌活性和治疗功效。这篇综述描述了细菌和纳米酶的治疗机制，其次是制备细菌/纳米酶复合材料的策略总结。此外,强调了这种复合材料在生物医学应用如胃肠道疾病和肿瘤中的协同作用。最后,讨论了细菌/纳米酶复合材料的挑战，并提出了潜在的解决方案。本研究旨在提供有价值的见解，为纳米材料辅助细菌治疗的发展提供理论指导。
