Abstract：
During behavior, the motor cortex sends copies of motor-related signals to sensory cortices. Here, we combine closed-loop behavior with large-scale physiology, projection-pattern-specific recordings, and circuit perturbations to show that neurons in mouse secondary motor cortex (M2) encode sensation and are influenced by expectation. When a movement unexpectedly produces a sound, M2 becomes dominated by sound-evoked activity. Sound responses in M2 are inherited partially from the auditory cortex and are routed back to the auditory cortex, providing a path for the reciprocal exchange of sensory-motor information during behavior. When the acoustic consequences of a movement become predictable, M2 responses to self-generated sounds are selectively gated off. These changes in single-cell responses are reflected in population dynamics, which are influenced by both sensation and expectation. Together, these findings reveal the embedding of sensory and expectation signals in motor cortical activity.
摘要：
在行为期间，运动皮层将运动相关信号的副本发送到感觉皮层。这里,我们将闭环行为与大规模生理学相结合，特定于投影模式的录音，和电路扰动表明小鼠次级运动皮层（M2）中的神经元编码感觉并受期望的影响。当一个动作意外地产生声音时，M2变得由声音诱发的活动主导。M2中的声音反应部分从听觉皮层继承，并返回听觉皮层，为行为过程中感觉运动信息的相互交换提供了一条路径。当运动的声学后果变得可预测时，对自产生的声音的M2响应被选择性地关闭。这些单细胞反应的变化反映在种群动态中，受感觉和期望的影响。一起,这些发现揭示了运动皮层活动中的感觉和期望信号的嵌入。
