Abstract：
BACKGROUND: Acne vulgaris (AV) is an inflammatory skin disorder leading to scars and discomfort, its intensity has major psychological consequences such as depression.
OBJECTIVE: To investigate the effect of isotretinoin (ISO) on NF-κB/NLRP3, biotinidase, and HMGB and correlation with depression.
METHODS: This was a case-control study that involved two groups. Group 1 is 20 healthy control, and group 2 is 20 patients diagnosed with AV according to Global Acne Grading System (GAGS) and received 20 mg ISO for 2 months. Before and after therapy, the Hamilton Depression Rating Scale (HDRS) was applied to assess each participant\'s level of depression. Nuclear factor kappa B (NF-ĸB), biotinidase, high mobility group box protein (HMGB1), nucleotide-binding domain, leucine-rich-containing family, and pyrin domain-containing-3 (NLRP-3) were measured in serum samples.
RESULTS: There was no significant difference in all measured markers of healthy group before and after 2 months. Regarding group 2, there was a statistically significant decrease in all measured markers after 2 months of treatment and significant correlations between GAGS, NF-ĸB, HMGB1, NLRP3, biotinidase, and depression score.
CONCLUSIONS: Increased GAGS, HMGB1, NLRP3, and biotinidase were associated with depression severity in AV patients and ISO treatment significantly reduced these parameters and reduced depressive symptoms.
OBJECTIVE: To investigate the effect of isotretinoin (ISO) on NF-κB/NLRP3, biotinidase, and HMGB and correlation with depression.
METHODS: This was a case-control study that involved two groups. Group 1 is 20 healthy control, and group 2 is 20 patients diagnosed with AV according to Global Acne Grading System (GAGS) and received 20 mg ISO for 2 months. Before and after therapy, the Hamilton Depression Rating Scale (HDRS) was applied to assess each participant\'s level of depression. Nuclear factor kappa B (NF-ĸB), biotinidase, high mobility group box protein (HMGB1), nucleotide-binding domain, leucine-rich-containing family, and pyrin domain-containing-3 (NLRP-3) were measured in serum samples.
RESULTS: There was no significant difference in all measured markers of healthy group before and after 2 months. Regarding group 2, there was a statistically significant decrease in all measured markers after 2 months of treatment and significant correlations between GAGS, NF-ĸB, HMGB1, NLRP3, biotinidase, and depression score.
CONCLUSIONS: Increased GAGS, HMGB1, NLRP3, and biotinidase were associated with depression severity in AV patients and ISO treatment significantly reduced these parameters and reduced depressive symptoms.
摘要：
背景：寻常痤疮（AV）是一种导致疤痕和不适的炎症性皮肤病，它的强度有主要的心理后果，如抑郁症。
目的：研究异维A酸(ISO)对NF-κB/NLRP3、HMGB与抑郁的相关性。
方法：这是一项病例对照研究，涉及两组。第一组是20名健康对照，第2组是根据全球痤疮分级系统（GAGS）诊断为AV的20例患者，并接受20mgISO治疗2个月。治疗前后,采用汉密尔顿抑郁量表（HDRS）评估每位参与者的抑郁水平。核因子κB（NF-B），生物素酶，高迁移率族框蛋白（HMGB1），核苷酸结合域，富含亮氨酸的家族，在血清样品中测量含pyrin结构域-3(NLRP-3)。
结果：在2个月之前和之后，健康组的所有测量指标均无显着差异。关于第2组，在治疗2个月后，所有测量的标志物均有统计学上的显着降低，并且GAGS之间存在显着相关性，NF-B，HMGB1，NLRP3，生物素酶，和抑郁评分。
结论：GAGS增加，HMGB1，NLRP3和生物素酶与AV患者的抑郁严重程度相关，ISO治疗显着降低了这些参数并减轻了抑郁症状。
目的：研究异维A酸(ISO)对NF-κB/NLRP3、HMGB与抑郁的相关性。
方法：这是一项病例对照研究，涉及两组。第一组是20名健康对照，第2组是根据全球痤疮分级系统（GAGS）诊断为AV的20例患者，并接受20mgISO治疗2个月。治疗前后,采用汉密尔顿抑郁量表（HDRS）评估每位参与者的抑郁水平。核因子κB（NF-B），生物素酶，高迁移率族框蛋白（HMGB1），核苷酸结合域，富含亮氨酸的家族，在血清样品中测量含pyrin结构域-3(NLRP-3)。
结果：在2个月之前和之后，健康组的所有测量指标均无显着差异。关于第2组，在治疗2个月后，所有测量的标志物均有统计学上的显着降低，并且GAGS之间存在显着相关性，NF-
结论：GAGS增加，HMGB1，NLRP3和生物素酶与AV患者的抑郁严重程度相关，ISO治疗显着降低了这些参数并减轻了抑郁症状。
