%0 Journal Article
%T Correlation between depression scores and serum NF-ĸB/NLRP3 axis, biotinidase, and HMGB1 after treatment with isotretinoin in patients with acne vulgaris.
%A Binsaleh AY
%A Ali LS
%A Bahaa MM
%A Elmasry TA
%A Negm WA
%A Hamouda AO
%A Salahuddin MM
%A Wahsh E
%A El-Samongy MA
%A Alsubaie N
%A El-Khateeb E
%A Yasser M
%A Eltantawy N
%J J Cosmet Dermatol
%V 0
%N 0
%D 2024 Jun 24
%M 38923374
%F 2.189
%R 10.1111/jocd.16433
%X <B>BACKGROUND: </B>Acne vulgaris (AV) is an inflammatory skin disorder leading to scars and discomfort, its intensity has major psychological consequences such as depression.<BR><B>OBJECTIVE: </B>To investigate the effect of isotretinoin (ISO) on NF-κB/NLRP3, biotinidase, and HMGB and correlation with depression.<BR><B>METHODS: </B>This was a case-control study that involved two groups. Group 1 is 20 healthy control, and group 2 is 20 patients diagnosed with AV according to Global Acne Grading System (GAGS) and received 20 mg ISO for 2 months. Before and after therapy, the Hamilton Depression Rating Scale (HDRS) was applied to assess each participant's level of depression. Nuclear factor kappa B (NF-ĸB), biotinidase, high mobility group box protein (HMGB1), nucleotide-binding domain, leucine-rich-containing family, and pyrin domain-containing-3 (NLRP-3) were measured in serum samples.<BR><B>RESULTS: </B>There was no significant difference in all measured markers of healthy group before and after 2 months. Regarding group 2, there was a statistically significant decrease in all measured markers after 2 months of treatment and significant correlations between GAGS, NF-ĸB, HMGB1, NLRP3, biotinidase, and depression score.<BR><B>CONCLUSIONS: </B>Increased GAGS, HMGB1, NLRP3, and biotinidase were associated with depression severity in AV patients and ISO treatment significantly reduced these parameters and reduced depressive symptoms.