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Abstract：
The biology of trophoblast cell lineage development and placentation is characterized by the involvement of several known transcription factors. Central to the action of a subset of these transcriptional regulators is CBP-p300 interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2). CITED2 acts as a coregulator modulating transcription factor activities and affecting placental development and adaptations to physiological stressors. These actions of CITED2 on the trophoblast cell lineage and placentation are conserved across the mouse, rat, and human. Thus, aspects of CITED2 biology in hemochorial placentation can be effectively modeled in the mouse and rat. In this review, we present information on the conserved role of CITED2 in the biology of placentation and discuss the use of CITED2 as a tool to discover new insights into regulatory mechanisms controlling placental development.
摘要：
滋养层细胞谱系发育和胎盘形成的生物学特征在于涉及几种已知的转录因子。这些转录调节子部分的作用的核心是CBP-p300与富含Glu/Asp的羧基末端结构域2（CITED2）相互作用的反式激活因子。CITED2充当调节转录因子活性并影响胎盘发育和对生理应激源的适应的共调节因子。CITED2对滋养层细胞谱系和胎盘的这些作用在小鼠中是保守的，rat,和人类。因此，CITED2生物学在血幕胎盘形成方面可以在小鼠和大鼠中有效建模。在这次审查中,我们提供了有关CITED2在胎盘形成生物学中的保守作用的信息，并讨论了CITED2作为发现控制胎盘发育的调控机制的新见解的工具。
