PDF(Pubmed)
Abstract：
The clinical magnetic resonance scanner (field strength ≤ 3.0 T) has limited efficacy in the high-resolution imaging of experimental mice. This study introduces a novel magnetic resonance micro-coil designed to enhance the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR), thereby improving high-resolution imaging in experimental mice using clinical magnetic resonance scanners. Initially, a phantom was utilized to determine the maximum spatial resolution achievable by the novel micro-coil. Subsequently, 12 C57BL/6JGpt mice were included in this study, and the novel micro-coil was employed for their scanning. A clinical flexible coil was selected for comparative analysis. The scanning methodologies for both coils were consistent. The imaging clarity, noise, and artifacts produced by the two coils on mouse tissues and organs were subjectively evaluated, while the SNR and CNR of the brain, spinal cord, and liver were objectively measured. Differences in the images produced by the two coils were compared. The results indicated that the maximum spatial resolution of the novel micro-coil was 0.2 mm. Furthermore, the subjective evaluation of the images obtained using the novel micro-coil was superior to that of the flexible coil (p < 0.05). The SNR and CNR measurements for the brain, spinal cord, and liver using the novel micro-coil were significantly higher than those obtained with the flexible coil (p < 0.001). Our study suggests that the novel micro-coil is highly effective in enhancing the image quality of clinical magnetic resonance scanners in experimental mice.
摘要：
临床磁共振扫描仪（场强≤3.0T）在实验小鼠的高分辨率成像中的功效有限。这项研究介绍了一种新颖的磁共振微线圈，旨在提高信噪比（SNR）和对比度噪声比（CNR），从而使用临床磁共振扫描仪改善实验小鼠的高分辨率成像。最初，一个体模被用来确定由新型微线圈可实现的最大空间分辨率。随后，本研究包括12只C57BL/6JGpt小鼠，并采用新型微线圈进行扫描。选择临床柔性线圈进行比较分析。两个线圈的扫描方法是一致的。成像清晰度，噪音,并对小鼠组织和器官上的两个线圈产生的伪影进行主观评估，而大脑的SNR和CNR，脊髓,并对肝脏进行了客观测量。比较由两个线圈产生的图像的差异。结果表明，新型微线圈的最大空间分辨率为0.2mm。此外，使用新型微线圈获得的图像的主观评价优于柔性线圈（p<0.05）。大脑的SNR和CNR测量，脊髓,使用新型微线圈的肝脏显着高于使用柔性线圈获得的肝脏（p<0.001）。我们的研究表明，新型微线圈在增强实验小鼠临床磁共振扫描仪的图像质量方面非常有效。
