RESULTS: A total of 37 individuals (18 PAD patients and 19 matched controls) underwent 3.0T CE-MRI. Skeletal calf muscle T1 mapping was performed before and after gadolinium contrast with a motion-corrected modified look-locker inversion recovery (MOLLI) pulse sequence. T1 values were calculated with a three-parameter Levenberg-Marquardt curve fitting algorithm. ECV and T1 maps were quantified in five calf muscle compartments (anterior [AM], lateral [LM], and deep posterior [DM] muscle groups; soleus [SM] and gastrocnemius [GM] muscles). Averaged peak blood pool T1 values were obtained from the posterior and anterior tibialis and peroneal arteries. T1 values and ECV are heterogeneous across calf muscle compartments. Native peak T1 values of the AM, LM, and DM were significantly higher in PAD patients compared to controls (all p < 0.028). ECVs of the AM and SM were significantly higher in PAD patients compared to controls (AM: 26.4% (21.2, 31.6) vs. 17.3% (10.2, 25.1), p = 0.046; SM: 22.7% (19.5, 27.8) vs. 13.8% (10.2, 19.1), p = 0.020).
CONCLUSIONS: Native peak T1 values across all five calf muscle compartments, and ECV fractions of the anterior muscle group and the soleus muscle were significantly elevated in PAD patients compared with matched controls. Non-invasive T1 mapping and ECV quantification may be of interest for the study of PAD.
结果:共有37名个体(18名PAD患者和19名匹配的对照)接受了3.0TCE-MRI检查。在钆对比之前和之后,使用运动校正的改良外观锁定器反转恢复(MOLLI)脉冲序列进行骨骼肌小腿肌肉T1映射。使用三参数Levenberg-Marquardt曲线拟合算法计算T1值。在五个小腿肌肉区室中对ECV和T1图进行了量化(前[AM],横向[LM],和深后[DM]肌群;比目鱼[SM]和腓肠肌[GM]肌肉)。从胫骨前后动脉和腓骨动脉获得平均峰值血池T1值。T1值和ECV在小腿肌肉区室中是异质的。AM的固有峰值T1值,LM,与对照组相比,PAD患者的DM和DM明显更高(均p<0.028)。与对照组相比,PAD患者的AM和SM的ECV明显更高(AM:26.4%(21.2,31.6)与17.3%(10.2、25.1),p=0.046;SM:22.7%(19.5,27.8)与13.8%(10.2,19.1),p=0.020)。
结论:所有五个小腿肌肉区室的天然T1峰值,与对照组相比,PAD患者的前肌组和比目鱼肌ECV分数显着升高。非侵入性T1映射和ECV定量可能对PAD的研究感兴趣。