PDF(Pubmed)
Abstract：
The monitoring of contaminants in fish species is pivotal for fishes\' health and reproduction, as well as for human health. In the specific work, three major categories of contaminants, pesticides, pharmaceuticals, and macro and trace elements, were investigated in two major fish species, Dicentrarchus labrax and Solea solea, collected from Thermaikos Gulf, in Greece. To achieve this goal, three analytical methods using LC-MS/MS, GC-MS/MS, and ICP-MS were developed, validated, and applied to the collected fish samples. The results indicated a very low prevalence of caffeine and acetaminophen, both not exceeding 3.8 μg/kg fish. Similarly, thiabendazole, cypermethrin, and tricyclazole (pesticides) were found in a concentration range of 0.9 to 13.7 μg/kg fish, while in one D. labrax sample, traces of the metabolite of organochlorine pesticide DDT, o,p\'-DDE were detected. Al, Mn, Fe, Zn, and Sr were the predominant trace elements in a concentration range of 500-20,000 μg/kg fish. Macro elements levels varied from 280 to 5405 mg/kg fish. Health risk assessment did not unveil an unacceptable risk for the human health of adults, apart from one sample presenting Hg above the regulatory levels. On the contrary, for children, the calculated hazard quotient values for Hg in all cases and for two As detections were higher than the threshold value of 1, indicating a potential risk.
摘要：
监测鱼类中的污染物对鱼类的健康和繁殖至关重要，以及人类健康。在具体工作中,三大类污染物，杀虫剂,制药，宏观和微量元素，在两种主要鱼类中进行了调查，双entrarchuslabrax和Soleasorea，从Thermaikos海湾收集，在希腊。为了实现这一目标,使用LC-MS/MS的三种分析方法，GC-MS/MS,并开发了ICP-MS，已验证，并应用于收集的鱼类样本。结果表明咖啡因和对乙酰氨基酚的患病率非常低，均不超过3.8μg/kg鱼。同样，噻菌灵,氯氰菊酯,和三环唑（农药）的浓度范围为0.9至13.7μg/kg鱼，在一个D.labrax样本中，有机氯农药滴滴涕代谢物的痕迹，a,检测到p'-DDE。Al,Mn,Fe,Zn,Sr是主要的微量元素，浓度范围为500-20,000μg/kg鱼。宏观元素水平从280到5405毫克/千克鱼不等。健康风险评估没有揭示成年人健康不可接受的风险，除了一个样品的汞含量高于监管水平。相反,对于孩子们来说,在所有病例和两次As检测中计算出的Hg风险商值均高于阈值1,表明存在潜在风险.
