PDF(Pubmed)
Abstract：
Two new meroterpenoids, aspergienynes O and P (1 and 2), one new natural compound, aspergienyne Q (3), and a new α-pyrone derivative named 3-(4-methoxy-2-oxo-2H-pyran-6-yl)butanoic acid (4) were isolated from the mangrove endophytic fungal strain Aspergillus sp. GXNU-Y85, along with five known compounds (5-9). The absolute configurations of those new isolates were confirmed through extensive analysis using spectroscopic data (HRESIMS, NMR, and ECD). The pharmacological study of the anti-proliferation activity indicated that isolates 5 and 9 displayed moderate inhibitory effects against HeLa and A549 cells, with the IC50 values ranging from 16.6 to 45.4 μM.
摘要：
两种新的类固醇,AspergienynesO和P（1和2），一种新的天然化合物，aspergienyneQ（3），并从红树林内生真菌菌株曲霉属中分离出一种新的α-吡喃衍生物，名为3-（4-甲氧基-2-氧代-2H-吡喃-6-基）丁酸（4）。GXNU-Y85,连同五个已知的化合物(5-9)。这些新分离株的绝对构型通过使用光谱数据的广泛分析得到证实(HRESIMS，NMR,和ECD）。抗增殖活性的药理学研究表明，分离株5和9对HeLa和A549细胞具有中等抑制作用，IC50值在16.6至45.4μM的范围内。
