PDF(Pubmed)
Abstract：
Cyclic glycine-proline (cGP), a prevalent marine cyclic dipeptide, possesses a distinct pyrrolidine-2,5-dione scaffold, which contributes to the chemical diversity and broad bioactivities of cGP. The diverse sources from marine-related, endogenous biological, and synthetic pathways and the in vitro and in vivo activities of cGP are reviewed. The potential applications for cGP are also explored. In particular, the pivotal roles of cGP in regulating insulin-like growth factor-1 homeostasis, enhancing neuroprotective effects, and improving neurotrophic function in central nervous system diseases are described. The potential roles of this endogenous cyclic peptide in drug development and healthcare initiatives are also highlighted. This review underscores the significance of cGP as a fundamental building block in drug discovery with exceptional drug-like properties and safety. By elucidating the considerable value of cGP, this review aims to reignite interest in cGP-related research within marine medicinal chemistry and synthetic biology.
摘要：
环状甘氨酸-脯氨酸(cGP)，一种普遍的海洋环状二肽，拥有独特的吡咯烷-2,5-二酮支架，这有助于cGP的化学多样性和广泛的生物活性。来自海洋相关的各种来源，内源性生物，综述了cGP的合成途径和体内外活性。还探讨了cGP的潜在应用。特别是,cGP在调节胰岛素样生长因子-1稳态中的关键作用，增强神经保护作用，描述了在中枢神经系统疾病中改善神经营养功能的方法。还强调了这种内源性环肽在药物开发和医疗保健计划中的潜在作用。这篇评论强调了cGP作为药物发现中具有特殊药物性质和安全性的基本组成部分的重要性。通过阐明CGP的重要价值，这篇综述旨在重新激发人们对海洋药物化学和合成生物学中cGP相关研究的兴趣。
