PDF(Pubmed)
Abstract：
Developing novel, safe, and efficient proangiogenic drugs is an important approach for the prevention and treatment of cardiovascular diseases. In this study, 4 new compounds, including 3 azaphilones (1-3) and 1 dihydroisocoumarin (4), as well as 13 known compounds (5-17), were isolated from the sea-mud-derived fungus Neopestalotiopsis sp. HN-1-6 from the Beibu Gulf of China. The structures of the new compounds were determined by NMR, MS, ECD, and NMR calculations. Compounds 3, 5, and 7 exhibited noteworthy proangiogenic activities in a zebrafish model at a concentration of 40 μM, without displaying cytotoxicity toward five human cell lines. In addition, some compounds demonstrated antibacterial effects against Staphylococcus aureus, Escherichia coli, and Candida albicans, with MIC values ranging from 64 μg/mL to 256 μg/mL.
摘要：
发展小说，安全,有效的促血管生成药物是预防和治疗心血管疾病的重要途径。在这项研究中,4个新化合物，包括3个氮杂吡酮（1-3）和1个二氢异香豆素（4），以及13种已知的化合物（5-17），从海泥来源的真菌Neopestalotiopsissp。中分离出来。来自中国北部湾的HN-1-6。通过NMR确定了新化合物的结构，MS,ECD,和NMR计算。化合物3、5和7在斑马鱼模型中表现出显著的促血管生成活性,浓度为40μM,对五种人类细胞系没有显示细胞毒性。此外,一些化合物对金黄色葡萄球菌具有抗菌作用，大肠杆菌,和白色念珠菌,MIC值范围为64μg/mL至256μg/mL。
