PDF(Pubmed)
Abstract：
Two new polyketide derivatives, penirubenones A and B (1 and 2), and two naturally rare amino-bis-tetrahydrofuran derivatives, penirubenamides A and B (3 and 4), together with nine known compounds (5-13) were isolated from the marine-derived fungus Penicillium rubens BTBU20213035. The structures were identified by HRESIMS and 1D and 2D NMR analyses, and their absolute configurations were determined by a comparison of experimental and calculated electronic circular dichroism (ECD) spectroscopy and 13C NMR data. We found that 6 exhibited antibacterial activity against Staphylococcus aureus, with an MIC value of 3.125 μg/mL, and 1 and 2 showed synergistic antifungal activity against Candida albicans at 12.5 and 50 μg/mL with 0.0625 μg/mL rapamycin.
摘要：
两种新的聚酮衍生物，吡喃酮A和B（1和2），和两种天然稀有的氨基-双-四氢呋喃衍生物，吡草胺A和B（3和4），与9种已知的化合物（5-13）一起从海洋来源的真菌红斑青霉BTBU20213035中分离。通过HRESIMS和1D和2DNMR分析鉴定了结构，通过比较实验和计算的电子圆二色性（ECD）光谱和13CNMR数据来确定它们的绝对构型。我们发现6对金黄色葡萄球菌具有抗菌活性，MIC值为3.125μg/mL，和1和2在12.5和50μg/mL与0.0625μg/mL雷帕霉素下显示出对白色念珠菌的协同抗真菌活性。
