%0 Journal Article
%T Secondary Metabolites from Marine-Derived Fungus Penicillium rubens BTBU20213035.
%A Xu X
%A Dong Y
%A Yang J
%A Wang L
%A Ma L
%A Song F
%A Ma X
%J J Fungi (Basel)
%V 10
%N 6
%D 2024 Jun 16
%M 38921410
%F 5.724
%R 10.3390/jof10060424
%X Two new polyketide derivatives, penirubenones A and B (1 and 2), and two naturally rare amino-bis-tetrahydrofuran derivatives, penirubenamides A and B (3 and 4), together with nine known compounds (5-13) were isolated from the marine-derived fungus Penicillium rubens BTBU20213035. The structures were identified by HRESIMS and 1D and 2D NMR analyses, and their absolute configurations were determined by a comparison of experimental and calculated electronic circular dichroism (ECD) spectroscopy and 13C NMR data. We found that 6 exhibited antibacterial activity against Staphylococcus aureus, with an MIC value of 3.125 μg/mL, and 1 and 2 showed synergistic antifungal activity against Candida albicans at 12.5 and 50 μg/mL with 0.0625 μg/mL rapamycin.