PDF(Pubmed)
Abstract：
Komagataella phaffii (formerly Pichia pastoris) is a methylotrophic yeast widely used in laboratories around the world to produce recombinant proteins. Given its advantageous features, it has also gained much interest in the context of modern biotechnology. In this review, we present the utilization of K. phaffii as a platform to produce several products of economic interest such as biopharmaceuticals, renewable chemicals, fuels, biomaterials, and food/feed products. Finally, we present synthetic biology approaches currently used for strain engineering, aiming at the production of new bioproducts.
摘要：
Komagataellaphaffii（前身为巴斯德毕赤酵母）是一种甲基营养酵母，在世界各地的实验室中广泛用于生产重组蛋白。鉴于其优点，它在现代生物技术的背景下也获得了极大的兴趣。在这次审查中,我们提出了利用K.phafii作为生产几种经济利益产品的平台，如生物制药，可再生化学品,燃料，生物材料,食品/饲料产品。最后,我们提出了目前用于菌株工程的合成生物学方法，旨在生产新的生物产品。
