{Reference Type}: Journal Article
{Title}: Applications of the Methylotrophic Yeast Komagataella phaffii in the Context of Modern Biotechnology.
{Author}: Moraes LMP;Marques HF;Reis VCB;Coelho CM;Leitão MC;Galdino AS;Porto de Souza TP;Piva LC;Perez ALA;Trichez D;de Almeida JRM;De Marco JL;Torres FAG;
{Journal}: J Fungi (Basel)
{Volume}: 10
{Issue}: 6
{Year}: 2024 Jun 6
{Factor}: 5.724
{DOI}: 10.3390/jof10060411
{Abstract}: Komagataella phaffii (formerly Pichia pastoris) is a methylotrophic yeast widely used in laboratories around the world to produce recombinant proteins. Given its advantageous features, it has also gained much interest in the context of modern biotechnology. In this review, we present the utilization of K. phaffii as a platform to produce several products of economic interest such as biopharmaceuticals, renewable chemicals, fuels, biomaterials, and food/feed products. Finally, we present synthetic biology approaches currently used for strain engineering, aiming at the production of new bioproducts.