关键词: bone engineering nanostructures oral cavity tissue engineering

来  源:   DOI:10.3390/biomimetics9060348   PDF(Pubmed)

Abstract:
OBJECTIVE: Two of the most exciting new technologies are biotechnology and nanotechnology. The science of nanostructures, or nanotechnology, is concerned with the development, testing, and use of structures and molecules with nanoscale dimensions ranging from 1 to 100 nm. The development of materials and tools with high specificity that interact directly at the subcellular level is what makes nanotechnology valuable in the medical sciences. At the cellular or tissue level, this might be converted into focused clinical applications with the greatest possible therapeutic benefits and the fewest possible side effects. The purpose of the present study was to review the literature and explore the applicability of the nanostructured materials in the process of the regeneration of the soft and hard tissues of the oral cavity.
METHODS: An electronic search of articles was conducted in several databases, such as PubMed, Embase, and Web of Science, to conduct this study, and the 183 articles that were discovered were chosen and examined, and only 22 articles met the inclusion criteria in this review.
RESULTS: The findings of this study demonstrate that using nanoparticles can improve the mechanical properties, biocompatibility, and osteoinductivity of biomaterials.
CONCLUSIONS: Most recently, breakthroughs in tissue engineering and nanotechnology have led to significant advancements in the design and production of bone graft substitutes and hold tremendous promise for the treatment of bone abnormalities. The creation of intelligent nanostructured materials is essential for various applications and therapies, as it allows for the precise and long-term delivery of medication, which yields better results.
摘要:
目的:两种最令人兴奋的新技术是生物技术和纳米技术。纳米结构的科学,或者纳米技术,与发展有关,测试,以及使用纳米级尺寸为1至100nm的结构和分子。在亚细胞水平上直接相互作用的具有高特异性的材料和工具的开发使纳米技术在医学科学中具有价值。在细胞或组织水平,这可能会转化为具有最大可能的治疗益处和最少可能的副作用的重点临床应用。本研究的目的是回顾文献,探索纳米结构材料在口腔软组织和硬组织再生过程中的适用性。
方法:在几个数据库中对文章进行了电子搜索,比如PubMed,Embase,和WebofScience,为了进行这项研究,对发现的183篇文章进行了选择和检查,只有22篇文章符合本次综述的纳入标准。
结果:这项研究的结果表明,使用纳米颗粒可以改善机械性能,生物相容性,和生物材料的骨诱导性。
结论:最近,组织工程和纳米技术的突破已经导致了骨移植替代物的设计和生产的重大进步,并为骨异常的治疗带来了巨大的希望。智能纳米结构材料的创造对于各种应用和治疗至关重要,因为它允许精确和长期的药物输送,这会产生更好的结果。
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