PDF(Pubmed)
Abstract：
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) complex, is a zoonotic disease that remains one of the leading causes of death worldwide. Latent tuberculosis infection reactivation is a challenging obstacle to eradicating TB globally. Understanding the gene regulatory network of Mtb during dormancy is important. This review discusses up-to-date information about TB gene regulatory networks during dormancy, focusing on the regulation of lipid and energy metabolism, dormancy survival regulator (DosR), White B-like (Wbl) family, Toxin-Antitoxin (TA) systems, sigma factors, and MprAB. We outline the progress in vaccine and drug development associated with Mtb dormancy.
摘要：
结核病(TB),由结核分枝杆菌（Mtb）复合体引起，是一种人畜共患疾病，仍然是全球主要的死亡原因之一。潜伏结核病感染的再激活是全球根除结核病的一个具有挑战性的障碍。了解休眠期间Mtb的基因调控网络非常重要。这篇综述讨论了有关休眠期间结核病基因调控网络的最新信息，专注于调节脂质和能量代谢，休眠生存调节剂（DosR），白色B样（Wbl）家族，毒素-抗毒素（TA）系统，西格玛因子，还有Mprab.我们概述了与Mtb休眠相关的疫苗和药物开发的进展。
