{Reference Type}: Journal Article
{Title}: Gene Regulatory Mechanism of Mycobacterium Tuberculosis during Dormancy.
{Author}: Liu Y;Li H;Dai D;He J;Liang Z;
{Journal}: Curr Issues Mol Biol
{Volume}: 46
{Issue}: 6
{Year}: 2024 Jun 11
{Factor}: 2.976
{DOI}: 10.3390/cimb46060348
{Abstract}: Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) complex, is a zoonotic disease that remains one of the leading causes of death worldwide. Latent tuberculosis infection reactivation is a challenging obstacle to eradicating TB globally. Understanding the gene regulatory network of Mtb during dormancy is important. This review discusses up-to-date information about TB gene regulatory networks during dormancy, focusing on the regulation of lipid and energy metabolism, dormancy survival regulator (DosR), White B-like (Wbl) family, Toxin-Antitoxin (TA) systems, sigma factors, and MprAB. We outline the progress in vaccine and drug development associated with Mtb dormancy.