PDF(Pubmed)
Abstract：
Bacterial cellulose is a biocompatible biomaterial with a unique macromolecular structure. Unlike plant-derived cellulose, bacterial cellulose is produced by certain bacteria, resulting in a sustainable material consisting of self-assembled nanostructured fibers with high crystallinity. Due to its purity, bacterial cellulose is appealing for biomedical applications and has raised increasing interest, particularly in the context of 3D printing for tissue engineering and regenerative medicine applications. Bacterial cellulose can serve as an excellent bioink in 3D printing, due to its biocompatibility, biodegradability, and ability to mimic the collagen fibrils from the extracellular matrix (ECM) of connective tissues. Its nanofibrillar structure provides a suitable scaffold for cell attachment, proliferation, and differentiation, crucial for tissue regeneration. Moreover, its mechanical strength and flexibility allow for the precise printing of complex tissue structures. Bacterial cellulose itself has no antimicrobial activity, but due to its ideal structure, it serves as matrix for other bioactive molecules, resulting in a hybrid product with antimicrobial properties, particularly advantageous in the management of chronic wounds healing process. Overall, this unique combination of properties makes bacterial cellulose a promising material for manufacturing hydrogels and 3D-printed scaffolds, advancing the field of tissue engineering and regenerative medicine.
摘要：
细菌纤维素是一种具有独特大分子结构的生物相容性生物材料。与植物来源的纤维素不同,细菌纤维素是由某些细菌产生的，产生由具有高结晶度的自组装纳米结构纤维组成的可持续材料。由于它的纯度，细菌纤维素对生物医学应用具有吸引力，并引起了越来越多的兴趣，特别是在3D打印用于组织工程和再生医学应用的背景下。细菌纤维素可以作为3D打印中的优秀生物墨水，由于其生物相容性，生物降解性，以及模拟结缔组织的细胞外基质（ECM）的胶原纤维的能力。它的纳米纤丝结构为细胞附着提供了合适的支架，扩散,和差异化，对组织再生至关重要。此外，其机械强度和灵活性允许复杂的组织结构的精确打印。细菌纤维素本身没有抗菌活性，但是由于其理想的结构，它作为其他生物活性分子的基质，产生具有抗菌特性的混合产品，特别有利于慢性伤口愈合过程的管理。总的来说,这种独特的特性组合使细菌纤维素成为制造水凝胶和3D打印支架的有前途的材料，推进组织工程和再生医学领域。
