Abstract：
The process of wound healing is intricate and requires close coordination; any disruption to this process can have catastrophic results. It is hypothesized that chronic wounds that do not heal or that cease healing entirely can be caused by a combination of host factors and bacteria that are present in a wound bed or wound bed environment. There is currently a lack of understanding regarding the role that the cutaneous microbiome plays in the healing process of wounds, despite the fact that methods that do not rely on culture have revealed the role that the gut microbiome plays in human health and illness. In order to keep the host immune system in check, protect the epithelial barrier function, and ward off harmful microbes, skin commensals play a crucial role. This review compiles the research on the effects of microbiome modifications on wound healing and tissue regeneration from both clinical and pre-clinical investigations on a variety of chronic skin wounds. It is now clear that human skin commensals, symbionts, and pathogens all play a part in the inflammatory response, which in turn suggests a number of ways to treat wounds that are infected and not healing. To fully understand the function of the human skin microbiome in both short-term and long-term wound healing, additional study is required to reconcile the conflicting and contentious results of previous investigations.
摘要：
伤口愈合的过程错综复杂，需要密切协调；对该过程的任何破坏都可能产生灾难性的结果。假设不愈合或完全停止愈合的慢性伤口可由存在于伤口床或伤口床环境中的宿主因子和细菌的组合引起。目前对皮肤微生物组在伤口愈合过程中的作用缺乏了解，尽管不依赖培养的方法已经揭示了肠道微生物组在人类健康和疾病中的作用。为了控制宿主的免疫系统,保护上皮屏障功能，抵御有害微生物，皮肤共生起着至关重要的作用。这篇综述汇集了对各种慢性皮肤伤口的临床和临床前研究中微生物组修饰对伤口愈合和组织再生的影响的研究。现在很明显，人类的皮肤共生，共生体,和病原体都在炎症反应中起作用，这反过来又提出了许多方法来治疗感染和不愈合的伤口。为了充分了解人体皮肤微生物组在短期和长期伤口愈合中的作用，需要额外的研究来调和以前调查中相互矛盾和有争议的结果.
