Abstract：
Methamphetamine (METH), an amphetamine-type stimulant, has been extensively abused globally in the past decades. METH use causes great harm to the major systems of the human body. Specifically, METH has a negative impact on the hypothalamic- pituitary-testicular axis, testicular structure, sperm function, ovarian folliculogenesis, oocyte quality, embryo development, and newborns. However, the mechanisms underlying these toxic effects have not yet been fully described. This study reviews the evidence concerning the impact of METH on male and female reproduction in the context of the testis, sperm, ovaries, oocytes, reproductive hormones, embryo development, and newborns, discussing the potential pathophysiological mechanisms in the reproductive toxicity induced by METH.
摘要：
甲基苯丙胺（METH），安非他明类兴奋剂,在过去的几十年里，在全球范围内被广泛滥用。METH的使用对人体的主要系统造成很大的危害。具体来说,METH对下丘脑-垂体-睾丸轴有负面影响，睾丸结构,精子功能，卵巢卵泡发生，卵母细胞质量,胚胎发育,和新生儿。然而,这些毒性作用的潜在机制尚未得到充分描述.这项研究回顾了有关METH在睾丸背景下对男性和女性生殖影响的证据，精子,卵巢,卵母细胞，生殖激素,胚胎发育,和新生儿，探讨METH引起生殖毒性的潜在病理生理机制。
