PDF(Pubmed)
Abstract：
UNASSIGNED: The interaction between the renin-angiotensin system (RAS) and the acute ischemic stroke (AIS) is definite but not fully understood. This study aimed to analyze the risk factors of AIS and explore the role of serum indicators such as angiotensin I (Ang I) in the prognosis of patients undergoing endovascular thrombectomy (EVT).
UNASSIGNED: Patients with AIS who underwent EVT and healthy controls were retrospectively enrolled in this study, and the patients were divided into a good or a poor prognosis group. We compared Ang I, blood routine indexes, biochemical indexes, electrolyte indexes, and coagulation indexes between patients and controls. We used univariate and multivariate logistic regression analyses to evaluate possible risk factors for AIS and the prognosis of patients undergoing EVT. Independent risk factors for the prognosis of patients undergoing EVT were identified through multifactorial logistic regression analyses to construct diagnostic nomograms, further assessed by receiver operating characteristic curves (ROC).
UNASSIGNED: Consistent with previous studies, advanced age, high blood glucose, high D-dimer, and high prothrombin activity are risk factors for AIS. In addition, Ang I levels are lower in AIS compared to the controls. The level of Ang I was higher in the good prognosis group. Furthermore, we developed a nomogram to evaluate its ability to predict the prognosis of AIS after EVT. The AUC value of the combined ROC model (Ang I and albumin-globulin ratio (AGR)) was 0.859.
UNASSIGNED: In conclusion, advanced age, high blood glucose, high D-dimer, and high prothrombin activity are risk factors for AIS. The combined Ang I and AGR model has a good predictive ability for the prognosis of AIS patients undergoing arterial thrombectomy.
UNASSIGNED: Patients with AIS who underwent EVT and healthy controls were retrospectively enrolled in this study, and the patients were divided into a good or a poor prognosis group. We compared Ang I, blood routine indexes, biochemical indexes, electrolyte indexes, and coagulation indexes between patients and controls. We used univariate and multivariate logistic regression analyses to evaluate possible risk factors for AIS and the prognosis of patients undergoing EVT. Independent risk factors for the prognosis of patients undergoing EVT were identified through multifactorial logistic regression analyses to construct diagnostic nomograms, further assessed by receiver operating characteristic curves (ROC).
UNASSIGNED: Consistent with previous studies, advanced age, high blood glucose, high D-dimer, and high prothrombin activity are risk factors for AIS. In addition, Ang I levels are lower in AIS compared to the controls. The level of Ang I was higher in the good prognosis group. Furthermore, we developed a nomogram to evaluate its ability to predict the prognosis of AIS after EVT. The AUC value of the combined ROC model (Ang I and albumin-globulin ratio (AGR)) was 0.859.
UNASSIGNED: In conclusion, advanced age, high blood glucose, high D-dimer, and high prothrombin activity are risk factors for AIS. The combined Ang I and AGR model has a good predictive ability for the prognosis of AIS patients undergoing arterial thrombectomy.
摘要：
■肾素-血管紧张素系统（RAS）与急性缺血性中风（AIS）之间的相互作用是确定的，但尚未完全了解。本研究旨在分析AIS的危险因素,探讨血管紧张素I(AngI)等血清指标在血管内血栓切除术(EVT)患者预后中的作用。
■接受EVT的AIS患者和健康对照者回顾性纳入本研究，并将患者分为预后良好或不良组。我们比较了AngI,血常规指标,生化指标,电解质指数，患者和对照组之间的凝血指标。我们使用单变量和多变量逻辑回归分析来评估AIS的可能危险因素和接受EVT的患者的预后。通过多因素logistic回归分析构建诊断列线图，确定接受EVT患者预后的独立危险因素。通过受试者工作特征曲线（ROC）进一步评估。
■与以前的研究一致，高龄,高血糖,D-二聚体高,高凝血酶原活性是AIS的危险因素。此外,与对照相比，AIS中的AngI水平较低。预后良好组AngⅠ水平较高。此外，我们建立了列线图来评估其预测EVT后AIS预后的能力.联合ROC模型的AUC值(AngI和白蛋白-球蛋白比值(AGR))为0.859。
■总而言之，高龄,高血糖,D-二聚体高,高凝血酶原活性是AIS的危险因素。AngI和AGR联合模型对动脉取栓AIS患者的预后具有良好的预测能力。
■接受EVT的AIS患者和健康对照者回顾性纳入本研究，并将患者分为预后良好或不良组。我们比较了AngI,血常规指标,生化指标,电解质指数，患者和对照组之间的凝血指标。我们使用单变量和多变量逻辑回归分析来评估AIS的可能危险因素和接受EVT的患者的预后。通过多因素logistic回归分析构建诊断列线图，确定接受EVT患者预后的独立危险因素。通过受试者工作特征曲线（ROC）进一步评估。
■与以前的研究一致，高龄,高血糖,D-二聚体高,高凝血酶原活性是AIS的危险因素。此外,与对照相比，AIS中的AngI水平较低。预后良好组AngⅠ水平较高。此外，我们建立了列线图来评估其预测EVT后AIS预后的能力.联合ROC模型的AUC值(AngI和白蛋白-球蛋白比值(AGR))为0.859。
■总而言之，高龄,高血糖,D-二聚体高,高凝血酶原活性是AIS的危险因素。AngI和AGR联合模型对动脉取栓AIS患者的预后具有良好的预测能力。
