PDF(Pubmed)
Abstract：
UNASSIGNED: The meta-analysis aimed to explore the cardiac adaptation in hypothyroidism patients by cardiac magnetic resonance.
UNASSIGNED: Databases including PubMed, Cochrane Library, Embase, CNKI, and Sinomed for clinical studies of hypothyroidism on cardiac function changes. Databases were searched from the earliest data to 15 June 2023. Two authors retrieved studies and evaluated their quality. Review Manager 5.4.1 and Stata18 were used to analyze the data. This study is registered with the International Platform of Registered Systematic Review and Meta-analysis Protocols (INPLASY), 202440114.
UNASSIGNED: Six studies were selected for further analysis. Five of them reported differences in cardiac function measures between patients with hypothyroidism and healthy controls, and three studies reported cardiac function parameters after treatment in patients with hypothyroidism. The fixed-effect model combined WMD values for left ventricular ejection fraction (LVEF) had a pooled effect size of -1.98 (95% CI -3.50 to -0.44], P=0.01), implying that LVEF was lower in patients with hypothyroidism than in healthy people. Analysis of heterogeneity found moderate heterogeneity (P = 0.08, I² = 50%). WMD values for stroke volume (SV), cardiac index (CI), left ventricular end-diastolic volume index(LVEDVI), left ventricular end-systolic volume (LESVI), and left ventricular mass index(LVMI) were also analyzed, and pooled effect sizes showed the CI and LVEDVI of patients with hypothyroidism ware significantly decrease (WMD=-0.47, 95% CI [-0.93 to -0.00], P=0.05, WMD=-7.99, 95%CI [-14.01 to -1.96], P=0.009, respectively). Patients with hypothyroidism tended to recover cardiac function after treatment [LVEF (WMD = 6.37, 95%CI [2.05, 10.69], P=0.004), SV (WMD = 7.67, 95%CI [1.61, 13.74], P=0.01), CI (WMD = 0.40, 95%CI [0.01, 0.79], P=0.05)], and there was no difference from the healthy controls.
UNASSIGNED: Hypothyroidism could affect cardiac function, although this does not cause significant heart failure. It may be an adaptation of the heart to the hypothyroid state. There was a risk that this adaptation may turn into myocardial damage. Cardiac function could be restored after treatment in patients with hypothyroidism. Aggressive levothyroxine replacement therapy should be used to reverse cardiac function.
UNASSIGNED: https://inplasy.com, identifier (INPLASY202440114).
UNASSIGNED: Databases including PubMed, Cochrane Library, Embase, CNKI, and Sinomed for clinical studies of hypothyroidism on cardiac function changes. Databases were searched from the earliest data to 15 June 2023. Two authors retrieved studies and evaluated their quality. Review Manager 5.4.1 and Stata18 were used to analyze the data. This study is registered with the International Platform of Registered Systematic Review and Meta-analysis Protocols (INPLASY), 202440114.
UNASSIGNED: Six studies were selected for further analysis. Five of them reported differences in cardiac function measures between patients with hypothyroidism and healthy controls, and three studies reported cardiac function parameters after treatment in patients with hypothyroidism. The fixed-effect model combined WMD values for left ventricular ejection fraction (LVEF) had a pooled effect size of -1.98 (95% CI -3.50 to -0.44], P=0.01), implying that LVEF was lower in patients with hypothyroidism than in healthy people. Analysis of heterogeneity found moderate heterogeneity (P = 0.08, I² = 50%). WMD values for stroke volume (SV), cardiac index (CI), left ventricular end-diastolic volume index(LVEDVI), left ventricular end-systolic volume (LESVI), and left ventricular mass index(LVMI) were also analyzed, and pooled effect sizes showed the CI and LVEDVI of patients with hypothyroidism ware significantly decrease (WMD=-0.47, 95% CI [-0.93 to -0.00], P=0.05, WMD=-7.99, 95%CI [-14.01 to -1.96], P=0.009, respectively). Patients with hypothyroidism tended to recover cardiac function after treatment [LVEF (WMD = 6.37, 95%CI [2.05, 10.69], P=0.004), SV (WMD = 7.67, 95%CI [1.61, 13.74], P=0.01), CI (WMD = 0.40, 95%CI [0.01, 0.79], P=0.05)], and there was no difference from the healthy controls.
UNASSIGNED: Hypothyroidism could affect cardiac function, although this does not cause significant heart failure. It may be an adaptation of the heart to the hypothyroid state. There was a risk that this adaptation may turn into myocardial damage. Cardiac function could be restored after treatment in patients with hypothyroidism. Aggressive levothyroxine replacement therapy should be used to reverse cardiac function.
UNASSIGNED: https://inplasy.com, identifier (INPLASY202440114).
摘要：
■本荟萃分析旨在通过心脏磁共振来探讨甲状腺功能减退症患者的心脏适应。
■包括PubMed、科克伦图书馆,Embase,CNKI,甲状腺功能减退症对心功能变化的临床研究。从最早的数据搜索到2023年6月15日的数据库。两位作者检索了研究并评估了其质量。使用ReviewManager5.4.1和Stata18对数据进行分析。本研究已在国际注册系统评价和荟萃分析协议平台（INPLASY）注册，202440114。
■选择了六项研究进行进一步分析。其中5人报告了甲状腺功能减退患者和健康对照组之间的心功能指标差异，三项研究报告了甲状腺功能减退症患者治疗后的心功能参数。固定效应模型结合左心室射血分数（LVEF）的WMD值的合并效应大小为-1.98（95％CI-3.50至-0.44]，P=0.01),这意味着甲状腺功能减退症患者的LVEF低于健康人。异质性分析发现中度异质性（P=0.08，I²=50％）。每搏输出量(SV)的WMD值,心脏指数（CI），左心室舒张末期容积指数(LVEDVI),左心室收缩末期容积（LESVI），和左心室质量指数（LVMI）也进行了分析，合并效应大小显示甲状腺功能减退患者的CI和LVEDVI显着降低（WMD=-0.47，95％CI[-0.93至-0.00]，P=0.05，WMD=-7.99，95CI[-14.01至-1.96]，分别为P=0.009)。甲状腺功能减退患者治疗后心功能趋于恢复[LVEF(WMD=6.37,95CI[2.05,10.69],P=0.004),SV（WMD=7.67，95CI[1.61，13.74]，P=0.01),CI（WMD=0.40，95CI[0.01，0.79]，P=0.05)],与健康对照组没有差异。
■甲状腺功能减退会影响心功能，虽然这不会导致严重的心力衰竭。这可能是心脏对甲状腺功能减退状态的适应。这种适应可能会导致心肌损伤。甲状腺功能减退症患者经治疗后可恢复心功能。积极的左甲状腺素替代疗法应用于逆转心功能。
■https://inplasy.com,标识符(INPLASY202440114)。
■包括PubMed、科克伦图书馆,Embase,CNKI,甲状腺功能减退症对心功能变化的临床研究。从最早的数据搜索到2023年6月15日的数据库。两位作者检索了研究并评估了其质量。使用ReviewManager5.4.1和Stata18对数据进行分析。本研究已在国际注册系统评价和荟萃分析协议平台（INPLASY）注册，202440114。
■选择了六项研究进行进一步分析。其中5人报告了甲状腺功能减退患者和健康对照组之间的心功能指标差异，三项研究报告了甲状腺功能减退症患者治疗后的心功能参数。固定效应模型结合左心室射血分数（LVEF）的WMD值的合并效应大小为-1.98（95％CI-3.50至-0.44]，P=0.01),这意味着甲状腺功能减退症患者的LVEF低于健康人。异质性分析发现中度异质性（P=0.08，I²=50％）。每搏输出量(SV)的WMD值,心脏指数（CI），左心室舒张末期容积指数(LVEDVI),左心室收缩末期容积（LESVI），和左心室质量指数（LVMI）也进行了分析，合并效应大小显示甲状腺功能减退患者的CI和LVEDVI显着降低（WMD=-0.47，95％CI[-0.93至-0.00]，P=0.05，WMD=-7.99，95CI[-14.01至-1.96]，分别为P=0.009)。甲状腺功能减退患者治疗后心功能趋于恢复[LVEF(WMD=6.37,95CI[2.05,10.69],P=0.004),SV（WMD=7.67，95CI[1.61，13.74]，P=0.01),CI（WMD=0.40，95CI[0.01，0.79]，P=0.05)],与健康对照组没有差异。
■甲状腺功能减退会影响心功能，虽然这不会导致严重的心力衰竭。这可能是心脏对甲状腺功能减退状态的适应。这种适应可能会导致心肌损伤。甲状腺功能减退症患者经治疗后可恢复心功能。积极的左甲状腺素替代疗法应用于逆转心功能。
■https://inplasy.com,标识符(INPLASY202440114)。
