Abstract：
OBJECTIVE: Chronic periodontitis leads to gingival swelling, hyperplasia, and tooth mobility, which affects orthodontic treatment. The aim of this study was to investigate the application of cefaclor in orthodontics through micro-implant anchorage in patients with periodontitis.
METHODS: A retrospective study was conducted on patients with periodontitis who received micro-implant anchorage treatment in the department of orthodontics at the First People\'s Hospital of Yongkang City from July 2019 to January 2022. According to different treatment regimens, these patients were divided into the test group (patients receiving cefaclor and micro-implant anchorage treatment) and the control group (patients receiving micro-implant anchorage treatment only). The plaque index (PLI), gingival index (GI), sulcus bleeding index (SBI), and serum inflammatory factor levels were compared between the two groups after treatment.
RESULTS: One hundred and five patients were included in the study, (44 males and 61 females, median age 21 [15-25] years), 51 in the cefaclor group and 54 in the no cefaclor group. After treatment, the PLI, GI, and SBI scores in the two groups were higher than those before treatment, and the levels of serum inflammatory markers significantly increased (p < 0.05). After treatment, the PLI, GI, and SBI scores in the test group were significantly lower than those in the control group (p < 0.001). The levels of serum interleukin-1β, interleukin-6, interleukin-8, and tumor necrosis factor-α were significantly lower in the test group, and the interleukin-2 level was higher in the test group (p < 0.001). There was no significant difference in the incidence of complications between the two groups (p > 0.05).
CONCLUSIONS: Cefaclor and micro-implant anchorage have a good clinical effect on orthodontics in patients with periodontitis, improving periodontal health and reducing inflammatory response.
METHODS: A retrospective study was conducted on patients with periodontitis who received micro-implant anchorage treatment in the department of orthodontics at the First People\'s Hospital of Yongkang City from July 2019 to January 2022. According to different treatment regimens, these patients were divided into the test group (patients receiving cefaclor and micro-implant anchorage treatment) and the control group (patients receiving micro-implant anchorage treatment only). The plaque index (PLI), gingival index (GI), sulcus bleeding index (SBI), and serum inflammatory factor levels were compared between the two groups after treatment.
RESULTS: One hundred and five patients were included in the study, (44 males and 61 females, median age 21 [15-25] years), 51 in the cefaclor group and 54 in the no cefaclor group. After treatment, the PLI, GI, and SBI scores in the two groups were higher than those before treatment, and the levels of serum inflammatory markers significantly increased (p < 0.05). After treatment, the PLI, GI, and SBI scores in the test group were significantly lower than those in the control group (p < 0.001). The levels of serum interleukin-1β, interleukin-6, interleukin-8, and tumor necrosis factor-α were significantly lower in the test group, and the interleukin-2 level was higher in the test group (p < 0.001). There was no significant difference in the incidence of complications between the two groups (p > 0.05).
CONCLUSIONS: Cefaclor and micro-implant anchorage have a good clinical effect on orthodontics in patients with periodontitis, improving periodontal health and reducing inflammatory response.
摘要：
目的：慢性牙周炎导致牙龈肿胀，增生,和牙齿的活动性，影响正畸治疗。本研究旨在探讨头孢克洛在牙周炎患者微种植体支抗正畸中的应用。
方法：对2019年7月至2022年1月永康市第一人民医院正畸科接受微种植体支抗治疗的牙周炎患者进行回顾性研究。根据不同的治疗方案，这些患者被分为试验组(接受头孢克洛和微种植体支抗治疗的患者)和对照组(仅接受微种植体支抗治疗的患者)。菌斑指数（PLI），牙龈指数（GI），沟出血指数（SBI），比较两组患者治疗后血清炎症因子水平。
结果：本研究纳入了105名患者，（男44人，女61人，中位年龄21[15-25]岁)，头孢克洛组51例，无头孢克洛组54例。治疗后,PLI,GI,两组SBI评分均高于治疗前,血清炎症标志物水平显著升高(p<0.05)。治疗后,PLI,GI,试验组SBI评分明显低于对照组(p<0.001)。血清白细胞介素-1β水平,白细胞介素-6、白细胞介素-8和肿瘤坏死因子-α在试验组中显著降低,试验组白细胞介素-2水平较高(p<0.001)。两组并发症发生率差异无统计学意义(p>0.05)。
结论：头孢克洛和微型种植体支抗在牙周炎患者正畸治疗中具有良好的临床效果。改善牙周健康，减少炎症反应。
方法：对2019年7月至2022年1月永康市第一人民医院正畸科接受微种植体支抗治疗的牙周炎患者进行回顾性研究。根据不同的治疗方案，这些患者被分为试验组(接受头孢克洛和微种植体支抗治疗的患者)和对照组(仅接受微种植体支抗治疗的患者)。菌斑指数（PLI），牙龈指数（GI），沟出血指数（SBI），比较两组患者治疗后血清炎症因子水平。
结果：本研究纳入了105名患者，（男44人，女61人，中位年龄21[15-25]岁)，头孢克洛组51例，无头孢克洛组54例。治疗后,PLI,GI,两组SBI评分均高于治疗前,血清炎症标志物水平显著升高(p<0.05)。治疗后,PLI,GI,试验组SBI评分明显低于对照组(p<0.001)。血清白细胞介素-1β水平,白细胞介素-6、白细胞介素-8和肿瘤坏死因子-α在试验组中显著降低,试验组白细胞介素-2水平较高(p<0.001)。两组并发症发生率差异无统计学意义(p>0.05)。
结论：头孢克洛和微型种植体支抗在牙周炎患者正畸治疗中具有良好的临床效果。改善牙周健康，减少炎症反应。
