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Abstract：
BACKGROUND: Despite the better prognosis associated with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC), some patients experience relapse and succumb to the disease; thus, there is a need for biomarkers identifying these patients for intensified treatment. Leucine-rich repeats and immunoglobulin-like domain (LRIG) protein 1 is a negative regulator of receptor tyrosine kinase signaling and a positive prognostic factor in OPSCC. Studies indicate that LRIG1 interacts with the LIM domain 7 protein (LMO7), a stabilizer of adherence junctions. Its role in OPSCC has not been studied before.
METHODS: A total of 145 patients diagnosed with OPSCC were enrolled. Immunohistochemical LMO7 expression and staining intensity were evaluated in the tumors and correlated with known clinical and pathological prognostic factors, such as HPV status and LRIG1, CD44, Ki67, and p53 expression.
RESULTS: Our results show that high LMO7 expression is associated with significantly longer overall survival (OS) (p = 0.044). LMO7 was a positive prognostic factor for OS in univariate analysis (HR 0.515, 95% CI: 0.267-0.994, p = 0.048) but not in multivariate analysis. The LMO7 expression correlated with LRIG1 expression (p = 0.048), consistent with previous findings. Interestingly, strong LRIG1 staining intensity was an independent negative prognostic factor in the HPV-driven group of tumors (HR 2.847, 95% Cl: 1.036-7.825, p = 0.043).
CONCLUSIONS: We show for the first time that high LMO7 expression is a positive prognostic factor in OPSCC, and we propose that LMO7 should be further explored as a biomarker. In contrast to previous reports, LRIG1 expression was shown to be an independent negative prognostic factor in HPV-driven OPSCC.
METHODS: A total of 145 patients diagnosed with OPSCC were enrolled. Immunohistochemical LMO7 expression and staining intensity were evaluated in the tumors and correlated with known clinical and pathological prognostic factors, such as HPV status and LRIG1, CD44, Ki67, and p53 expression.
RESULTS: Our results show that high LMO7 expression is associated with significantly longer overall survival (OS) (p = 0.044). LMO7 was a positive prognostic factor for OS in univariate analysis (HR 0.515, 95% CI: 0.267-0.994, p = 0.048) but not in multivariate analysis. The LMO7 expression correlated with LRIG1 expression (p = 0.048), consistent with previous findings. Interestingly, strong LRIG1 staining intensity was an independent negative prognostic factor in the HPV-driven group of tumors (HR 2.847, 95% Cl: 1.036-7.825, p = 0.043).
CONCLUSIONS: We show for the first time that high LMO7 expression is a positive prognostic factor in OPSCC, and we propose that LMO7 should be further explored as a biomarker. In contrast to previous reports, LRIG1 expression was shown to be an independent negative prognostic factor in HPV-driven OPSCC.
摘要：
背景：尽管人乳头瘤病毒（HPV）阳性口咽鳞状细胞癌（OPSCC）预后较好，一些患者经历复发并屈服于疾病；因此，需要识别这些患者的生物标志物以加强治疗.富含亮氨酸的重复序列和免疫球蛋白样结构域（LRIG）蛋白1是受体酪氨酸激酶信号传导的负调节因子，也是OPSCC的阳性预后因素。研究表明，LRIG1与LIM结构域7蛋白（LMO7）相互作用，粘附连接的稳定剂。其在OPSCC中的作用尚未被研究过。
方法：纳入145例OPSCC患者。免疫组织化学LMO7在肿瘤中的表达和染色强度进行评估，并与已知的临床和病理预后因素相关。如HPV状态和LRIG1、CD44、Ki67和p53表达。
结果：我们的结果表明，高LMO7表达与显着更长的总生存期（OS）相关（p=0.044）。在单因素分析中，LMO7是OS的阳性预后因素（HR0.515，95％CI：0.267-0.994，p=0.048），但在多因素分析中不是。LMO7表达与LRIG1表达相关(p=0.048),与以前的发现一致。有趣的是,强LRIG1染色强度是HPV驱动组肿瘤的独立阴性预后因素(HR2.847,95%Cl:1.036-7.825,p=0.043)。
结论：我们首次显示高LMO7表达是OPSCC的积极预后因素，我们建议LMO7作为生物标志物应该进一步探索。与以前的报告相比，LRIG1表达在HPV驱动的OPSCC中显示为独立的阴性预后因素。
方法：纳入145例OPSCC患者。免疫组织化学LMO7在肿瘤中的表达和染色强度进行评估，并与已知的临床和病理预后因素相关。如HPV状态和LRIG1、CD44、Ki67和p53表达。
结果：我们的结果表明，高LMO7表达与显着更长的总生存期（OS）相关（p=0.044）。在单因素分析中，LMO7是OS的阳性预后因素（HR0.515，95％CI：0.267-0.994，p=0.048），但在多因素分析中不是。LMO7表达与LRIG1表达相关(p=0.048),与以前的发现一致。有趣的是,强LRIG1染色强度是HPV驱动组肿瘤的独立阴性预后因素(HR2.847,95%Cl:1.036-7.825,p=0.043)。
结论：我们首次显示高LMO7表达是OPSCC的积极预后因素，我们建议LMO7作为生物标志物应该进一步探索。与以前的报告相比，LRIG1表达在HPV驱动的OPSCC中显示为独立的阴性预后因素。
