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Abstract：
BACKGROUND: Early-onset sepsis (EOS) is a serious illness that affects preterm newborns, and delayed antibiotic initiation may increase the risk of adverse outcomes.
OBJECTIVE: The objective of this study was to examine the present time of antibiotic administration in preterm infants with suspected EOS and the factors that contribute to delayed antibiotic initiation.
METHODS: In this retrospective study in China, a total of 82 early preterm infants with suspected EOS between December 2021 and March 2023 were included. The study utilized a linear regression analytical approach to identify independent factors that contribute to delayed antibiotic administration.
RESULTS: The mean gestational age and birth weight of the study population were 29.1 ± 1.4 weeks and 1265.7 ± 176.8 g, respectively. The median time of initial antibiotic administration was 3.8 (3.1-5.0) hours. Linear regression revealed that severe respiratory distress syndrome (RDS) (β = 0.07, P = 0.013), penicillin skin test (PST) timing (β = 0.06, P < 0.001) and medical order timing (β = 0.04, P = 0.017) were significantly associated with the initial timing of antibiotic administration.
CONCLUSIONS: There is an evident delay in antibiotic administration in preterm infants with suspected EOS in our unit. Severe RDS, PST postponement and delayed medical orders were found to be associated with the delayed use of antibiotics, which will be helpful for quality improvement efforts in the neonatal intensive care unit (NICU).
OBJECTIVE: The objective of this study was to examine the present time of antibiotic administration in preterm infants with suspected EOS and the factors that contribute to delayed antibiotic initiation.
METHODS: In this retrospective study in China, a total of 82 early preterm infants with suspected EOS between December 2021 and March 2023 were included. The study utilized a linear regression analytical approach to identify independent factors that contribute to delayed antibiotic administration.
RESULTS: The mean gestational age and birth weight of the study population were 29.1 ± 1.4 weeks and 1265.7 ± 176.8 g, respectively. The median time of initial antibiotic administration was 3.8 (3.1-5.0) hours. Linear regression revealed that severe respiratory distress syndrome (RDS) (β = 0.07, P = 0.013), penicillin skin test (PST) timing (β = 0.06, P < 0.001) and medical order timing (β = 0.04, P = 0.017) were significantly associated with the initial timing of antibiotic administration.
CONCLUSIONS: There is an evident delay in antibiotic administration in preterm infants with suspected EOS in our unit. Severe RDS, PST postponement and delayed medical orders were found to be associated with the delayed use of antibiotics, which will be helpful for quality improvement efforts in the neonatal intensive care unit (NICU).
摘要：
背景：早发性败血症（EOS）是一种影响早产新生儿的严重疾病，延迟使用抗生素可能会增加不良结局的风险.
目的：本研究的目的是研究怀疑有EOS的早产儿目前使用抗生素的时间，以及导致抗生素开始延迟的因素。
方法：在中国的这项回顾性研究中，纳入了2021年12月至2023年3月期间共82例疑似EOS的早期早产儿.该研究利用线性回归分析方法来确定导致抗生素延迟施用的独立因素。
结果：研究人群的平均胎龄和出生体重分别为29.1±1.4周和1265.7±176.8g，分别。初始抗生素给药的中位时间为3.8(3.1-5.0)小时。线性回归显示严重呼吸窘迫综合征(RDS)(β=0.07,P=0.013),青霉素皮试（PST）时间（β=0.06，P<0.001）和医嘱时间（β=0.04，P=0.017）与抗生素初始给药时间显着相关。
结论：本单位疑似EOS的早产儿抗生素给药明显延迟。严重RDS,PST推迟和延迟医嘱被发现与抗生素的延迟使用有关，这将有助于提高新生儿重症监护病房（NICU）的质量。
目的：本研究的目的是研究怀疑有EOS的早产儿目前使用抗生素的时间，以及导致抗生素开始延迟的因素。
方法：在中国的这项回顾性研究中，纳入了2021年12月至2023年3月期间共82例疑似EOS的早期早产儿.该研究利用线性回归分析方法来确定导致抗生素延迟施用的独立因素。
结果：研究人群的平均胎龄和出生体重分别为29.1±1.4周和1265.7±176.8g，分别。初始抗生素给药的中位时间为3.8(3.1-5.0)小时。线性回归显示严重呼吸窘迫综合征(RDS)(β=0.07,P=0.013),青霉素皮试（PST）时间（β=0.06，P<0.001）和医嘱时间（β=0.04，P=0.017）与抗生素初始给药时间显着相关。
结论：本单位疑似EOS的早产儿抗生素给药明显延迟。严重RDS,PST推迟和延迟医嘱被发现与抗生素的延迟使用有关，这将有助于提高新生儿重症监护病房（NICU）的质量。
