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Abstract：
The tumor microenvironment includes a complex network of immune T-cell subsets that play important roles in colorectal cancer (CRC) progression and are key elements of CRC immunotherapy. T cells develop and migrate within tumors, recognizing tumor-specific antigens to regulate immune surveillance. Current immunotherapies are divided into the following main categories based on the regulatory role of T-cell subsets in the tumor immune microenvironment (TIME): cytokines, monoclonal antibodies, peptide vaccines, CAR-T cells and more. This review describes the composition of the tumor immune microenvironment in colorectal cancer and the involvement of T cells in the pathogenesis and progression of CRC as well as current T-cell-related immunotherapies. Further studies on CRC-specific tumor antigens, the gene regulation of T cells, and the regulation of immune activity are needed.
摘要：
肿瘤微环境包括免疫T细胞亚群的复杂网络，在结直肠癌（CRC）的进展中起重要作用，并且是CRC免疫治疗的关键要素。T细胞在肿瘤内发育和迁移，识别肿瘤特异性抗原以调节免疫监视。根据T细胞亚群在肿瘤免疫微环境（TIME）中的调节作用，目前的免疫疗法分为以下几类：细胞因子，单克隆抗体，肽疫苗，CAR-T细胞等等。这篇综述描述了结直肠癌中肿瘤免疫微环境的组成，T细胞参与CRC的发病机理和进展以及当前T细胞相关的免疫治疗。对CRC特异性肿瘤抗原的进一步研究，T细胞的基因调控,并且需要调节免疫活性。
