{Reference Type}: Journal Article
{Title}: The tumor immune microenvironment and T-cell-related immunotherapies in colorectal cancer.
{Author}: Chuang L;Qifeng J;Shaolei Y;
{Journal}: Discov Oncol
{Volume}: 15
{Issue}: 1
{Year}: 2024 Jun 25
暂无{DOI}: 10.1007/s12672-024-01117-7
{Abstract}: The tumor microenvironment includes a complex network of immune T-cell subsets that play important roles in colorectal cancer (CRC) progression and are key elements of CRC immunotherapy. T cells develop and migrate within tumors, recognizing tumor-specific antigens to regulate immune surveillance. Current immunotherapies are divided into the following main categories based on the regulatory role of T-cell subsets in the tumor immune microenvironment (TIME): cytokines, monoclonal antibodies, peptide vaccines, CAR-T cells and more. This review describes the composition of the tumor immune microenvironment in colorectal cancer and the involvement of T cells in the pathogenesis and progression of CRC as well as current T-cell-related immunotherapies. Further studies on CRC-specific tumor antigens, the gene regulation of T cells, and the regulation of immune activity are needed.