Abstract：
OBJECTIVE: Our study\'s objective was to assess the incidence trends and healthcare resource utilization of hospitalizations for Tick-Borne Encephalitis (TBE) and associated costs in Italy in order to improve public awareness and preventive measures.
METHODS: This retrospective observational study was based on the Italian Ministry of Health\'s Hospital Discharge Record (HDR) database. Data were gathered across Italy from 2015 to 2019, selecting hospitalizations with ICD-9 code 063 related to TBE, both in primary and secondary diagnoses. For each year, we collected the following variables: number of hospitalizations, hospitalization rate, mortality rate, mean length of hospital stay, hospital ward, and cost of hospitalization.
RESULTS: There were a total of 237 hospitalizations from 2015 to 2019; 62 % of those were male. The lowest number of TBE hospitalizations was in 2015 (21 cases, corresponding to 0.35 per million inhabitants), the highest in 2019 (64 cases, 1.04 per million inhabitants). The summer months saw a greater than average number of hospitalizations. For the years analyzed, the cumulative number of cases peaked in June (54 cases), July (46 cases), and August (35 cases). There were only two deaths registered in our study sample. TBE cases were mostly localized in the North-Eastern regions of Italy. TBE incidence during the study period in the most affected areas were: Autonomous Province of Trento, ranging from 11.2 to 42.3 per million inhabitants, Autonomous Province of South Tyrol, from 0 to 21.1 per million inhabitants, and Veneto Region, from 2.6 to 4.5 per million inhabitants. In the study period, the average length of hospital stay was largely stable ranging from 10.6 days to 12.8 days, with related costs ranging from 5,813.7 € to 7,352.5 €.
CONCLUSIONS: According to our data, the majority of TBE hospitalizations occur in North-East Italy with an increasing trend over the analyzed period. Even though Italy has fewer TBE cases than other neighboring European countries, the health and economic impact can be high in the affected areas.
METHODS: This retrospective observational study was based on the Italian Ministry of Health\'s Hospital Discharge Record (HDR) database. Data were gathered across Italy from 2015 to 2019, selecting hospitalizations with ICD-9 code 063 related to TBE, both in primary and secondary diagnoses. For each year, we collected the following variables: number of hospitalizations, hospitalization rate, mortality rate, mean length of hospital stay, hospital ward, and cost of hospitalization.
RESULTS: There were a total of 237 hospitalizations from 2015 to 2019; 62 % of those were male. The lowest number of TBE hospitalizations was in 2015 (21 cases, corresponding to 0.35 per million inhabitants), the highest in 2019 (64 cases, 1.04 per million inhabitants). The summer months saw a greater than average number of hospitalizations. For the years analyzed, the cumulative number of cases peaked in June (54 cases), July (46 cases), and August (35 cases). There were only two deaths registered in our study sample. TBE cases were mostly localized in the North-Eastern regions of Italy. TBE incidence during the study period in the most affected areas were: Autonomous Province of Trento, ranging from 11.2 to 42.3 per million inhabitants, Autonomous Province of South Tyrol, from 0 to 21.1 per million inhabitants, and Veneto Region, from 2.6 to 4.5 per million inhabitants. In the study period, the average length of hospital stay was largely stable ranging from 10.6 days to 12.8 days, with related costs ranging from 5,813.7 € to 7,352.5 €.
CONCLUSIONS: According to our data, the majority of TBE hospitalizations occur in North-East Italy with an increasing trend over the analyzed period. Even though Italy has fewer TBE cases than other neighboring European countries, the health and economic impact can be high in the affected areas.
摘要：
目的：我们的研究目的是评估意大利Tick-Borne脑炎（TBE）住院的发病率趋势和医疗资源利用以及相关费用，以提高公众的认识和预防措施。
方法：这项回顾性观察研究基于意大利卫生部的出院记录（HDR）数据库。数据收集了2015年至2019年意大利各地的数据，选择了与TBE相关的ICD-9代码063的住院治疗，在主要和次要诊断中。每年,我们收集了以下变量：住院次数，住院率，死亡率,平均住院时间,医院病房,和住院费用。
结果：从2015年到2019年，共有237例住院；其中62％为男性。TBE住院人数最低的是2015年(21例，相当于每百万居民0.35)，2019年最高(64例，每百万居民1.04)。夏季的住院人数高于平均水平。在分析的几年里，累计病例数在6月达到峰值(54例)，7月（46例），8月（35例）。在我们的研究样本中只有两例死亡。TBE病例大多位于意大利的东北地区。在研究期间，受影响最严重的地区是：特伦托自治省，从每百万居民11.2到42.3不等，南蒂罗尔自治省，从每百万居民0到21.1，威尼托地区,从每百万居民2.6到4.5。在学习期间,平均住院时间基本稳定，从10.6天到12.8天，相关费用从5,813.7欧元到7,352.5欧元不等。
结论：根据我们的数据，大部分TBE住院发生在意大利东北部,且在分析期间呈上升趋势.尽管意大利的TBE病例比其他欧洲邻国少，受影响地区的健康和经济影响可能很大。
方法：这项回顾性观察研究基于意大利卫生部的出院记录（HDR）数据库。数据收集了2015年至2019年意大利各地的数据，选择了与TBE相关的ICD-9代码063的住院治疗，在主要和次要诊断中。每年,我们收集了以下变量：住院次数，住院率，死亡率,平均住院时间,医院病房,和住院费用。
结果：从2015年到2019年，共有237例住院；其中62％为男性。TBE住院人数最低的是2015年(21例，相当于每百万居民0.35)，2019年最高(64例，每百万居民1.04)。夏季的住院人数高于平均水平。在分析的几年里，累计病例数在6月达到峰值(54例)，7月（46例），8月（35例）。在我们的研究样本中只有两例死亡。TBE病例大多位于意大利的东北地区。在研究期间，受影响最严重的地区是：特伦托自治省，从每百万居民11.2到42.3不等，南蒂罗尔自治省，从每百万居民0到21.1，威尼托地区,从每百万居民2.6到4.5。在学习期间,平均住院时间基本稳定，从10.6天到12.8天，相关费用从5,813.7欧元到7,352.5欧元不等。
结论：根据我们的数据，大部分TBE住院发生在意大利东北部,且在分析期间呈上升趋势.尽管意大利的TBE病例比其他欧洲邻国少，受影响地区的健康和经济影响可能很大。
