Abstract：
Seizures are a concerning adverse event frequently associated with the use of psychedelics, and hence, studies involving these substances tend to exclude patients with past history of epilepsy. This is especially relevant because epileptic seizures are markedly increased in the population suffering from mental disorders, and psychedelic assisted therapy is being researched as a promising treatment for several of them. To determine the extent of the current literature on the relationship between classic psychedelics and seizures, a scoping review was performed using the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews). The search was conducted in PubMed, Web of Science, Google scholar, LILACS and Scielo, and both animal and human models were included. A total of 16 publications on humans, and 11 on animals, were found. The results are heterogeneous, but globally suggest that psychedelics may not increase the risk of seizures in healthy individuals or animals in the absence of other drugs. However, concomitant use of other substances or drugs, such as kambo or lithium, could increase the risk of seizures. Additionally, these conclusions are drawn from data lacking sufficient external validity, so they should be interpreted with caution. Future paths for research and a summary on possible neurobiological underpinnings that might clarify the relationship between classical psychedelics and seizures are also provided.
摘要：
癫痫发作是一种经常与使用迷幻药有关的不良事件，因此，涉及这些物质的研究倾向于排除既往有癫痫史的患者.这一点尤其重要，因为癫痫发作在患有精神疾病的人群中明显增加，迷幻辅助疗法正在研究中，作为一种有希望的治疗方法。为了确定当前有关经典迷幻药与癫痫发作之间关系的文献的范围，使用PRISMA-ScR（系统评价的首选报告项目和范围审查的Meta分析扩展）进行范围审查。搜索是在PubMed中进行的，WebofScience,谷歌学者，LILACS和Scielo,并包括动物和人体模型。共有16篇关于人类的出版物，11关于动物，被发现了。结果是异质的，但在全球范围内表明，在没有其他药物的情况下，迷幻药可能不会增加健康个体或动物的癫痫发作风险。然而,同时使用其他物质或药物，例如kambo或锂，可能会增加癫痫发作的风险。此外,这些结论是从缺乏足够外部有效性的数据中得出的，所以他们应该谨慎解释。还提供了未来的研究路径以及可能阐明经典迷幻药与癫痫发作之间关系的神经生物学基础的总结。
