PDF(Pubmed)
Abstract：
The current clinical application of glaucoma drainage devices is made of non-degradable materials. These non-degradable drainage devices often trigger inflammatory responses and scar proliferation, possibly leading to surgical failure. We developed a biodegradable material hydroxyapatite-coated magnesium (HA-Mg) as a glaucoma drainage device. Twelve New Zealand white rabbits were randomly assigned to three groups: HA-Mg drainage plate group (6 right eyes), trabeculectomy group (6 right eyes), and control group (12 left eyes). Results showed that all HA-Mg drainage plates were completely degraded ~4 months postoperatively. At the 5th month postoperatively, there was no statistical difference in the corneal endothelium density between the HA-Mg drainage plate group and the control group (p = 0.857). The intraocular pressure (IOP) level in the HA-Mg drainage plate implantation group was lower than in the other two groups. The trypan blue dye still drained from the anterior chamber to the subconjunctiva 5 months after HA-Mg drainage plate implantation. HE staining revealed the scleral linear aqueous humor drainage channel and anterior synechia were observed after drainage plate completely degraded, with no obvious infiltration with the inflammatory cells. This study showed the safety and efficacy of HA-Mg glaucoma drainage plate in controlling IOP after implantation into the anterior chamber of rabbit eyes.
摘要：
目前临床应用的青光眼引流装置均为非降解材料。这些不可降解的引流装置通常会引发炎症反应和疤痕增生，可能导致手术失败.我们开发了一种可生物降解的材料羟基磷灰石涂层镁（HA-Mg）作为青光眼引流装置。12只新西兰大白兔随机分为3组:HA-Mg引流板组(6只右眼),小梁切除术组（6只右眼），对照组(12只左眼)。结果表明，所有HA-Mg引流板在术后约4个月均完全降解。术后第5个月,HA-Mg引流板组与对照组的角膜内皮密度无统计学差异(p=0.857)。HA-Mg引流板植入组的眼压（IOP）水平低于其他两组。HA-Mg引流板植入后5个月，锥虫蓝染料仍从前房引流到结膜下。HE染色显示引流板完全降解后，巩膜线状房水引流通道和前粘连，无明显炎性细胞浸润。这项研究表明HA-Mg青光眼引流板在植入兔前房后控制IOP的安全性和有效性。
