PDF(Pubmed)
Abstract：
During the last decades, five or six member rings azaheterocycles compounds appear to be an extremely valuable source of antifungal agents. Their use seems to be a very attractive solution in antifungal therapy and to overcome antifungal resistance in agriculture. The present review highlights the main results obtained in the field of hybrid and chimeric azine (especially pyridine, quinoline, phenanthroline, bypyridine, naphthyridine and their fused derivatives) derivatives presented in scientific literature from the last 10 years, with emphasis on antifungal activity of the mentioned compounds. A special attention was played to hybrid and chimeric azole-azine class, having in view the high antifungal potential of azoles.
[Box: see text].
[Box: see text].
摘要：
在过去的几十年里，五元或六元环氮杂环化合物似乎是非常有价值的抗真菌剂来源。它们的使用似乎是抗真菌治疗中非常有吸引力的解决方案，并克服了农业中的抗真菌耐药性。本综述重点介绍了杂合和嵌合吖嗪(特别是吡啶，喹啉,菲咯啉,旁吡啶,萘啶及其稠合衍生物）在过去10年的科学文献中提出的衍生物，强调上述化合物的抗真菌活性。特别注意杂种和嵌合唑-嗪类，鉴于唑类药物的高抗真菌潜力。
[方框：见正文]。
[方框：见正文]。
